BIOAVAILABLE DELIVERY METHODS

LIPOSOMES DELIVER THE HIGHEST PERCENTAGE OF ACTIVE INGREDIENTS

Liposomes are specialized delivery vehicles composed of phospholipid molecules—the same molecules that comprise our cell membranes. A payload is encapsulated inside the liposome. This prevents them from being digested in the gastrointestinal tract or attacked as a foreign body in the bloodstream, so they can protect and deliver nutrients directly into cells throughout the body. (1)

Read more about the Liposome Advantage.

SUBLINGUAL PROVIDES THE FASTEST DELIVERY TO THE BLOODSTREAM

Sublingual delivery can provide rapid absorption via the blood vessels under the tongue rather than via the digestive tract. Most customers report an immediate boost in energy after use. Research suggests 20-30% of the product may be absorbed directly to the bloodstream, with the remainder being swallowed and subject to digestion in the gastro-intestinal tract.(1,2,3)

Read more about Sublingual delivery

TRANSDERMAL DELIVERY AVOIDS THE GI TRACT TO REACH CIRCULATION

Transdermal delivery is a method of applying medications or active ingredients through the skin. The skin's protective barrier creates a challenge for transdermal delivery. Our Renue™ skin care products use liposomes to carry ingredients past the skin’s barrier to deliver active ingredients deep into the skin and systemic circulation (5). Liposomes are an advanced delivery vehicle, offering superior stability of active ingredients, higher absorption and greater efficacy.

Learn More About Liposomes and Transdermal Delivery

INTRANASAL NAD+ IS IDEAL FOR DELIVERY TO THE BRAIN

Supplements administered using nasal delivery provide higher bioavailability, fewer side effects and result in higher brain exposure at a similar dosage than oral supplements.(1NAD+ is stable in liquids and in studies with mice, NAD+ has shown a particular affinity for the brain.  NAD+ has been shown to cross the blood brain barrier, while NMN and NR do not. (2,3)

Learn More About Intranasal Delivery

BIOAVAILABLE DELIVERY METHODS

LIPOSOMES DELIVER THE HIGHEST PERCENTAGE OF ACTIVE INGREDIENTS

Liposomes are specialized delivery vehicles composed of phospholipid molecules—the same molecules that comprise our cell membranes. A payload is encapsulated inside the liposome. This prevents them from being digested in the gastrointestinal tract or attacked as a foreign body in the bloodstream, so they can protect and deliver nutrients directly into cells throughout the body. (1)

Read more about the Liposome Advantage.

SUBLINGUAL PROVIDES THE FASTEST DELIVERY TO THE BLOODSTREAM

Sublingual delivery can provide rapid absorption via the blood vessels under the tongue rather than via the digestive tract. Most customers report an immediate boost in energy after use. Research suggests 20-30% of the product may be absorbed directly to the bloodstream, with the remainder being swallowed and subject to digestion in the gastro-intestinal tract.(1,2,3)

Read more about Sublingual delivery

TRANSDERMAL DELIVERY AVOIDS THE GI TRACT TO REACH CIRCULATION

Transdermal delivery is a method of applying medications or active ingredients through the skin. The skin's protective barrier creates a challenge for transdermal delivery. Our Renue™ skin care products use liposomes to carry ingredients past the skin’s barrier to deliver active ingredients deep into the skin and systemic circulation (5). Liposomes are an advanced delivery vehicle, offering superior stability of active ingredients, higher absorption and greater efficacy.

Learn More About Liposomes and Transdermal Delivery

INTRANASAL NAD+ IS IDEAL FOR DELIVERY TO THE BRAIN

Supplements administered using nasal delivery provide higher bioavailability, fewer side effects and result in higher brain exposure at a similar dosage than oral supplements.(1NAD+ is stable in liquids and in studies with mice, NAD+ has shown a particular affinity for the brain.  NAD+ has been shown to cross the blood brain barrier, while NMN and NR do not. (2,3)

Learn More About Intranasal Delivery

WHICH PRODUCT IS RIGHT FOR ME ?

In 2016 we pioneered Sublingual delivery of NMN, and since then have advanced the industry further with Intranasal, Transdermal, and Liposomal NMN products.

Here we compare each of these, highlighting their unique strengths to help you decide which product is right for you.

– more –

ABOUT LIPOSOMES

Liposomes are a revolutionary way of encapsulating active ingredients to protect and deliver them directly to the cells of our tissues, which are reached via the bloodstream. (1)

Liposomes stabilize therapeutic compounds – overcoming obstacles to cellular and tissue uptake – and improve the biodistribution of compounds to target sites. – more –

RESEARCH FINDS IMPROVED AEROBIC CAPACITY WITH NMN

In this six-week human study researchers conclude that supplementation of Nicotinamide Mononucleotide (NMN) remarkably lifted ventilatory threshold (VT) in amateur runners. The benefit was dose-dependent and muscle-related.

The randomized, double-blind, placebo-controlled, four-arm clinical trial includED 48 young and middle-aged recreationally trained runners of the Guangzhou Pearl River running team.

 – more –

RESEARCH ON LIPOSOMES

This study in mice found a 47-fold increase (in Cmax) with Liposomal Fisetin. The chart at right shows blood plasma levels are much higher with Liposomal Fisetin vs free Fisetin at 10x higher dosage

In vivo, liposomal fisetin allowed a 47-fold increase in relative bioavailability compared to free fisetin.

 – more –

BIOAVAILABILITY ISSUES WITH NAD+ PRECURSORS

When taken as oral supplements, NAD+ and its precursors are almost entirely degraded to Nicotinamide (NAM) in the stomach, intestines, and liver, greatly diminishing the effectiveness. (1,2,3,4,5)

Delivery methods that avoid digestion and deliver the product intact to cells throughout the body are needed to realize the potential of NAD+ Boosters. – more –

NMN OR NR?

NMN and NR are very similar, but both have very poor bioavailability and if not improved, a tiny fraction are able to make it to the bloodstream and reach tissues throughout the body.

We believe both have advantages and disadvantages, but delivery methods that improve the bioavailability are far more important than which molecule is used. – more –

 

WHICH PRODUCT IS RIGHT FOR ME ?

In 2016 we pioneered Sublingual delivery of NMN, and since then have advanced the industry further with Intranasal, Transdermal, and Liposomal NMN products.

Here we compare each of these, highlighting their unique strengths to help you decide which product is right for you.

– more –

ABOUT LIPOSOMES

Liposomes are a revolutionary way of encapsulating active ingredients to protect and deliver them directly to the cells of our tissues, which are reached via the bloodstream. (1)

Liposomes stabilize therapeutic compounds – overcoming obstacles to cellular and tissue uptake – and improve the biodistribution of compounds to target sites. – more –

RESEARCH ON LIPOSOMES

This study in mice found a 47-fold increase (in Cmax) with Liposomal Fisetin. The chart at right shows blood plasma levels are much higher with Liposomal Fisetin vs free Fisetin at 10x higher dosage

In vivo, liposomal fisetin allowed a 47-fold increase in relative bioavailability compared to free fisetin.

 – more –

BIOAVAILABILITY ISSUES WITH NAD+ PRECURSORS

When taken as oral supplements, NAD+ and its precursors are almost entirely degraded to Nicotinamide (NAM) in the stomach, intestines, and liver, greatly diminishing the effectiveness. (1,2,3,4,5)

Delivery methods that avoid digestion and deliver the product intact to cells throughout the body are needed to realize the potential of NAD+ Boosters. – more –

NMN OR NR?

NMN and NR are very similar, but both have very poor bioavailability and if not improved, a tiny fraction are able to make it to the bloodstream and reach tissues throughout the body.

We believe both have advantages and disadvantages, but delivery methods that improve the bioavailability are far more important than which molecule is used. – more –

 

WHAT OUR CUSTOMERS SAY

"I take 125 mg before my workouts, 3-5 times a week. During resistance training I see an increased pump.

I finish with a rowing machine sprint, and taking NMN gives me a 5-10% increase in distance rowed. Very impressed with this stuff!" 

"I have a form of Retinitis Pigmentosa which has been sending me blind for the last 20 years at least. I have fought it with everything I had but was losing the fight in my late 30s. It wasn’t until I started the sublingual NMN that I felt definite vision improvements after only one week."

As part of J2Racing he has 3 in-class victories in the Carrera Cup Class of the VLN in recent years.

“I’m a committed bio-hacker with strong goals toward longevity. NAD maintenance is high on my list. I recommend this protocol to people every chance I get.”

"I am the Reigning 65-69 IRONMAN World Champion, a title earned in October 2017 in
Kona, Hawaii. I am able to detect a small “lift” when I take NMN.

I require less sleep and recover faster."

"I was taking the NMN tablets for two years, but find I like the NAD+ tablets and spray better, so have switched to those. At 61, I look at least 15 years younger than others my age. Results from Teloyears were even more encouraging as they showed my telomere length to be that of a 20 year old."

"It feels like I'm putting liquid gold on my arm. That's probably the best way to describe it.

This could be what prevents some of your aging. NAD+ is the fountain of youth. We all have NAD+ in our bodies but it decreases as we get older. I highly recommend this!"

"I LOVE these products! I've definitely noticed less redness and smoother skin around my eyes and forehead. They are the only ones I'd ever use going forward because I see actual results. Most creams and serums are overly expensive and truly don't do anything. I have spent so much money on luxury facial treatments in the past and now I will not be going back. I love the Renue skin care line.”

"I still have supple and youthful looking skin. Thanks, Renue! As a Triathlete who spends time outdoors a lot for training and racing, Renue products have made my skin look young again. I still have supple and youthful looking skin, and don't have much sun spots or damage from the sun. I look like I'm still in my late 20s, even though I just turned 40 this April!”

WHAT OUR CUSTOMERS SAY

"I take 125 mg before my workouts, 3-5 times a week. During resistance training I see an increased pump.

I finish with a rowing machine sprint, and taking NMN gives me a 5-10% increase in distance rowed. Very impressed with this stuff!" 

"I have a form of Retinitis Pigmentosa which has been sending me blind for the last 20 years at least. I have fought it with everything I had but was losing the fight in my late 30s. It wasn’t until I started the sublingual NMN that I felt definite vision improvements after only one week."

As part of J2Racing he has 3 in-class victories in the Carrera Cup Class of the VLN in recent years.

“I’m a committed bio-hacker with strong goals toward longevity. NAD maintenance is high on my list. I recommend this protocol to people every chance I get.”

"I am the Reigning 65-69 IRONMAN World Champion, a title earned in October 2017 in
Kona, Hawaii. I am able to detect a small “lift” when I take NMN.

I require less sleep and recover faster."

"I was taking the NMN tablets for two years, but find I like the NAD+ tablets and spray better, so have switched to those. At 61, I look at least 15 years younger than others my age. Results from Teloyears were even more encouraging as they showed my telomere length to be that of a 20 year old."

"It feels like I'm putting liquid gold on my arm. That's probably the best way to describe it.

This could be what prevents some of your aging. NAD+ is the fountain of youth. We all have NAD+ in our bodies but it decreases as we get older. I highly recommend this!"

"I LOVE these products! I've definitely noticed less redness and smoother skin around my eyes and forehead. They are the only ones I'd ever use going forward because I see actual results. Most creams and serums are overly expensive and truly don't do anything. I have spent so much money on luxury facial treatments in the past and now I will not be going back. I love the Renue skin care line.”

"I still have supple and youthful looking skin. Thanks, Renue! As a Triathlete who spends time outdoors a lot for training and racing, Renue products have made my skin look young again. I still have supple and youthful looking skin, and don't have much sun spots or damage from the sun. I look like I'm still in my late 20s, even though I just turned 40 this April!”