Research is clear that when taken as oral supplements, NAD+ and its precursors are almost entirely degraded to Nicotinamide (NAM) in the stomach, intestines, and liver, greatly diminishing the effectiveness. (1,2,3,4,5)

Delivery methods that avoid digestion and deliver the product intact to cells throughout the body are needed to realize the potential of NAD+ Boosters. – more about bioavailability problems


Liposomes are specialized delivery vehicles composed of phospholipid molecules—the same molecules that comprise our cell membranes. A payload is encapsulated inside the liposome. This prevents them from being digested in the gastrointestinal tract or attacked as a foreign body in the bloodstream, so they can protect and deliver nutrients directly into cells throughout the body (1).

Read more about the Liposome Advantage.


Sublingual delivery can provide rapid absorption via the blood vessels under the tongue rather than via the digestive tract. Most customers report an immediate boost in energy after use. Research suggests 20-30% of the product may be absorbed directly to the bloodstream, with the remainder being swallowed and subject to digestion in the gastro-intestinal tract.(1,2,3)

Read more about Sublingual delivery


Transdermal delivery is a method of applying medications or active ingredients through the skin. The skin's protective barrier creates a challenge for transdermal delivery. Our Renue™ skin care products use liposomes to carry ingredients past the skin’s barrier to deliver active ingredients deep into the skin and systemic circulation (5). Liposomes are an advanced delivery vehicle, offering superior stability of active ingredients, higher absorption and greater efficacy.

Learn More About Liposomes and Transdermal Delivery


Supplements  administered using nasal delivery have higher bioavailability, fewer side effects, and result in higher brain exposure at a similar dosage than do oral drugs.(1NAD+ is stable in liquids, and in studies with mice NAD+ has shown a particular affinity for the brain.  NAD+  has been shown to cross the blood brain barrier, while NMN and NR do not (2,3).

Learn More About Intranasal Delivery

If not protected, NMN, NR, and NAD+ are almost totally digested in the stomach, liver, and intestines. If present in the bloodstream, all are able to enter cells and raise NAD+ by a similar amount. The primary difference is stability in the bloodstream.

Nicotinamide Mononucleotide

NMN is more stable than NR and remains available in the bloodstream for many hours (1, 2) but not as stable as NAD+. Research in mice show it is able to restore NAD+ levels inside cells more effectively than NR or NAD+ (3).Other research in mice have shown very impressive benefits for endurance and new blood vessel growth. (4)

See our NMN products

Nicotinamide Riboside

NR is very unstable in the bloodstream (1) and is never found at more than trace levels (2). When given to human at 1,000 mg per day for 3 weeks, NR levels in the blood were not increased at all and still barely detectable (3).

To reach beyond the liver, delivering NR in liposomes that protect it from degradation in the bloodstream is the solution.

See our Liposomal NR product

Nicotinamide Adenine Dinucleotide

NAD+ is very stable in the bloodstream and well utilized by cells throughout the body (1,2,3,4,).Studies in mice show it is able to cross the blood brain barrier, while NMN and NR cannot (5), and may have more benefit on neurological issues. Very large dosages injected by IV in humans are well tolerated and is so quickly metabolized by cells there is no increase in extracellular NAD+ levels in plasma for 2 hours.After 2 hours, an increase of 4x and 5x was found in plasma NAD+ and NMN (6).

See our NAD+ Products

"I take 125 mg before my workouts, 3-5 times a week. During resistance training I see an increased pump.

I finish with a rowing machine sprint, and taking NMN gives me a 5-10% increase in distance rowed.

Very impressed with this stuff!" 

"I have a form of Retinitis Pigmentosa which has been sending me blind for the last 20 years at least. I have fought it with everything I had but was losing the fight in my late 30s. It wasn’t until I started the sublingual NMN that I felt definite vision improvements after only one week."

As part of J2Racing he has 3 in-class victories in the Carrera Cup Class of the VLN in recent years.

“I’m a committed bio-hacker with strong goals toward longevity. NAD maintenance is high on my list. I recommend this protocol to people every chance I get.”

"I am the Reigning 65-69 IRONMAN World Champion, a title earned in October 2017 in
Kona, Hawaii. I am able to detect a small “lift” when I take NMN.

I require less sleep and recover faster."

"I was taking the NMN tablets for two years, but find I like the NAD+ tablets and spray better, so have switched to those. At 61, I look at least 15 years younger than others my age. Results from Teloyears were even more encouraging as they showed my telomere length to be that of a 20 year old."

"It feels like I'm putting liquid gold on my arm. That's probably the best way to describe it.

This could be what prevents some of your aging. NAD+ is the fountain of youth. We all have NAD+ in our bodies but it decreases as we get older. I highly recommend this!"

"I LOVE these products!

I've definitely noticed less redness and smoother skin around my eyes and forehead. I LOVE these products! They are the only ones I'd ever use going forward because I see actual results. Most creams and serums are overly expensive and truly don't do anything. I have spent so much money on luxury facial treatments in the past and now I will not be going back. I love the Renue skin care line.”


As the industry leader and largest manufacturer of NAD+ products, we consult with a wide range of research and clinical doctors to understand the latest research and combine that with feedback from tens of thousands of customers on our forum and facebook group. This helps us learn so we can offer the best quality, most effective NAD+ restoration products at the absolute lowest price.


We move at lightning speed to bring the most innovative products to market, including sublingual powders, tablets, liquids, nasal sprays and improved delivery techniques for NAD+ and NMN IVs.


Fast and reliable shipping is part of our industry best customer service. We also have the most knowledgable personnel standing by to answer questions about the science and products.


We test every batch of our product three times throughout production and post the test reports online, so customers are assured they are getting exactly what the label says.