NAD+ and the Hallmarks of Aging Series – Part 6: Mitochondrial Dysfunction

Mitochondria – more than power plants in cells Mitochondria are the large organelles that exist in most human cells. They are the critical organelles that generate ATP through the respiratory chain and produce the intermediate metabolites that are [...]

First Randomized Clinical Trial: NMN increases muscle insulin sensitivity in prediabetic women

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women, Science, April 22, 2021 NAD+ is the critical cellular component for cellular homeostasis, which declines during the aging process. Various studies have shown that decreased NAD+ levels are associated [...]

Reduced Nicotinamide Mononucleotide – A Tale of Four NAD+ Precursors

NAD+ precursors and healthy aging Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells. It is a critical coenzyme for energy metabolism and also serves as the substrate for enzymes such as the sirtuins. One [...]

Why TOO MUCH NMN or NR is bad, and what you can do about it

If not protected, NMN and NR supplements are almost entirely degraded to NAM (Nicotinamide) before reaching tissues beyond the liver. While NAM is beneficial for many health conditions, excessive NAM levels can be detrimental to your health. “high [...]

NAD+ and the Hallmarks of Aging Series – Part 5: Deregulated Nutrient Sensing

Overview Currently, available evidence strongly supports the idea that anabolic signaling (the signal that promotes growth and proliferation) accelerates aging, and decreased nutrient signaling extends longevity (Fontana et al., 2010). Further, a pharmacological manipulation that mimics a state [...]

NAD+ and the Hallmarks of Aging Series – Part 4: Loss of Proteostasis

Cells are “factories” and proteins are “machines” In previous parts, we mainly discussed the mishaps that accumulate on the genome that cause aging. In this article, we will move our focus to protein. When talking about proteins, the [...]

NAD+ and the Hallmarks of Aging Series – Part 3: Epigenetic Alteration

What is epigenetics? It is well-known that the DNA sequence inside of the nucleus encodes all the information required for life. However, why do different cells/tissues work very differently even though they share the same genome? The answer [...]

NAD+ and the Hallmarks of Aging Series – Part 2: Telomere attrition

Telomere shortening is probably the most famous hallmark of aging, but what is the telomere’€s original function?   Telomeres protect the ends of chromosomes Every complex organism is based on the proliferation of the cells. The cells must [...]

NAD+ and the Hallmarks of Aging Series – Part 1: Genomic instability

Aging characterized by gradual loss of physiological integrity Aging is characterized by a gradual loss of physiological integrity, resulting in impaired biological function and increased vulnerability to diseases and death. In 2013, Lopez-otin et al first summarized the [...]

CD73 utilization shows importance of NMN to restore NAD+

This recent study found that in endothelial cells, the extracellular conversion of NMN to NR by CD73 enzyme in the cell membrane is a key mechanism to maintain intracellular NAD+ Reversal of endothelial dysfunction by nicotinamide mononucleotide via [...]

Is SLC12A8 a dedicated NMN transporter – Dr Stanfield questions Dr Brenner

Above is a response by Dr. Bradley Stanfield to some lingering questions that resulted from an interview he had of Dr. Charles Brenner on Dec. 6th, 2020. The original interview by Dr. Stanfield can be seen in it’s [...]

Bacteria in Gastrointestional Tract Metabolize NMN and Impact NAD+ Metabolome

This recently published research by Drs. Lindsay Wu, David Sinclair and others examined the pathways that oral NMN takes to becoming NAD+ in mice. It confirmed some aspects of earlier research, and also made some surprising new findings. [...]

NMN IS BIOAVAILABLE AND STABLE IN BLOOD – NR IS NOT

NMN IS STABLE IN THE BLOODSTREAM, NR IS NOT Bioavailability is the fraction of an administered dose of unchanged drug that reaches the systemic circulation Since the Rabinowitz study in 2018, we have known that both Nicotinamide Riboside [...]

NAD+ For Skin Care

An essential compound—known as NAD+—has found its way into skincare and is being hailed as a “true cosmeceutical.” [...]

Small Dose of NMN Restores Fertility in Old Mice, Large Dose Does Not – Implications for Dosage Suggestions

Recently published research shows that a small dose of NMN in the drinking water was able to improve the quality of eggs in older mice and reverse infertility. Researchers at the Universities of Queensland and New South Wales  [...]

Justin Bieber gets weekly IV drips of NAD+

  Justin Bieber gets weekly IV drips of NAD+ to help with the effects of his years of substance abuse   Justin Bieber opened up about his substance abuse, mental health, and recovery process on his new YouTube [...]

LSG – Liposomal Sublingual Gel – New delivery method

  LSG – combining the power of Liposomes & Sublingual delivery in our advanced Gel technology Liposomal Sublingual Gel (LSG™) is a novel nanoliposomal nutrient delivery system that utilizes pharmaceutical grade organic, non-GMO phospholipids designed to deliver unmetabolized [...]

NAD⁺ Injection Restores NAD⁺ Levels in Brain and Cognition in Mice

In a recent study, 18 male APP/PS1 mice were intraperitoneally injected with 30 mg/kg NAD⁺ at 20 weeks of age and once every other day for 4 weeks. These transgenic mice were used as they develop the behavioral [...]

1st NMN Human Study Demonstrates Safety and Faster Utilization than NR

The first study of NMN in humans was just published. https://www.jstage.jst.go.jp/…/advpub_EJ19-03…/_pdf/-char/en This japanese study looked at a single dose of 100, 250, or 500 mg NMN capsules to 10 men 40-60 years old. No adverse effects were noted. [...]

NMN Improves Cerebrovascular Function and Cognition in Mice

Decreased NAD+ levels are implicated in a wide range of age related impairments. There is  evidence that restoring NAD+ by treatment with nicotinamide mononucleotide (NMN) may reverse age-related dysfunction in multiple organs. For instance, prior research showed supplementation [...]

Slc12a8 does not solve the bioavailability problem for NMN Capsules

This research was published in January 2019 that found an enzyme named Slc12a8 that can transport a small quantity of Nicotinamide Mononucleotide (NMN) directly into some cells. However, this enzyme is only prevalent in the small intestine of [...]

Increased NAD+ in Bloodstream of Nursing Mice Results in Healthier, Stronger, Smarter Offspring

This study fed lactating mice Nicotinamide Riboside (NR) in chow for 21 days after birth of offspring to measure the effect on the health of their pups who did not receive any NR. After 21 days, the pups [...]

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Scientists discover pathway used by NMN to restore NAD+ levels

Yes, NMN can cross the cell membrane intact This research was just published that found an enzyme named Slc12a8 that can transport a small quantity of Nicotinamide Mononucleotide (NMN) directly into some cells However, this enzyme is only [...]

Fisetin – A Powerful Senolytic that Extends Health and Lifespan

    LSG Fisetin Solves the Bioavailability Problem Fisetin has poor bioavailability when taken orally. Studies show Liposomal Fisetin is up to 27x more bioavailable, which allows smaller dosages that put less strain on the liver. 3 Our [...]

Tru Niagen vs Basis

As you’re reading this, there are mind-boggling advances being made in longevity and anti-aging. In fact, just a couple of years ago, scientists were able to reverse the age of mice by up to 40 years simply by [...]

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Exogenous NAD+ Increases Metabolism

Effects of Chronic NAD Supplementation on Energy Metabolism and Diurnal Rhythm in Obese Mice In a study published in 2018, scientists gave obese mice 1 mg/kg of NAD+ by inter peritoneal injection for 4 weeks, which  restored NAD+ levels [...]

Is Basis by Elysium Health a Hoax?

The main ingredient in Elysium Health’s Basis is Nicotinamide Riboside (NR). Elysium Health is only one of several companies selling Nicotinamide Riboside (NR). Their main selling point is the 6 Nobel Prize winning scientists they have signed up [...]

NAD+ Supplements Regulate Energy Metabolism via the Hypothalamus

Exogenous nicotinamide adenine dinucleotide regulates energy metabolism via hypothalamic Connexin 43. There are some very important findings coming out of this research: Exogenous NAD+ definitely does cross the blood brain barrier through the Connexin 43 gap junction Exogenous [...]

NAD+ Supplements – Research and Benefits

Nicotinamide Adenide Dinucleotide (NAD+) and its immediate precursor Nicotinamide Mononucleotide (NMN) have both been shown to quickly elevate levels of NAD+ in various tissues and organs throughout the body. [...]

NMN product shows increased endurance and new blood vessel growth in mice

This new research, published March 22 in Cell, identifies the key cellular mechanisms behind vascular aging and the key role it plays on muscle health. Scientists at Harvard Medical School, Massachusetts Institute of Technology (MIT) and the University of [...]