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Is Basis by Elysium Health a Hoax?

The main ingredient in Elysium Health’s Basis is Nicotinamide Riboside (NR).

Elysium Health is only one of several companies selling Nicotinamide Riboside (NR). Their main selling point is the 6 Nobel Prize winning scientists they have signed up as advisors to their company. That is certainly very impressive and lends great credibility to the company.

However, these scientists have had no significant role in researching or creating the Nicotinamide Riboside or the Pterostilbene they combine with it to form their Basis product.

WHY BASIS – IS IT BETTER THAN OTHER BRANDS selling nr?

You won’t find any mention of Niagen in the sales and marketing literature about Basis.

Elysium would like you to think that Basis is an exclusive formula created by their founders.

In fact, until recently, they purchased Nicotinamide Riboside and Pterostilbene from Chromadex like several other brands.

Ongoing lawsuits between Chromadex and Elysium Health resulted in a new formulation for Basis that uses Nicotinamide Riboside they manufacture themselves.

There is no reason to believe Basis is any more effective than any other Nicotinamide Riboside.

NMN and nad+ supplements have advantages

Chromadex and Elysium Health are fighting over the patents for use of Nicotinamide Riboside with hopes to reap the windfalls that come with controlling the market.

However, the research that shows the most dramatic results in health from restoring NAD+ levels was actually accomplished by feeding mice Nicotinamide Mononucleotide (NMN). (r,r,r).

There have also been many studies showing benefits from using NAD+ injections in mice (r), but the obvious difficulty of using injections in humans has limited the interest.

Both NAD+ and NMN have significant advantages over NR for restoring NAD+ levels throughout the body.

Poor Bioavailability from Capsules

NAD+ is not effective in drinking water or in capsule form.
The NAD+ molecule is twice as large as NR or NMN, and is completely degraded in the gastrointestinal tract, so researchers do not use NAD+ in drinking water of mice and it is not sold in capsule form for humans.

NAD+ in IV or IP injections
Research has been successful using NAD+ injections in mice.

In humans, clinics that provide NAD+ by IV are exploding in popularity, even though they charge over $1,000 a day and require the patient to be hooked up to a drip IV for 8 hours.

Our Restoration Clinic in Ponte Vedra Beach, Florida offers 750 mg of pharmaceutical-grade, lyophilized NAD+ that is administered in less than 2-hours and is followed by a vitamin push that has 19 essential vitamins, minerals and amio acids. We see athletes, celebrities, high-level executives and everyone in between.

NMN and NR poor bioavailability in capsules
NMN and NR capsules are only partially digested in the stomach, but are almost totally metabolized in the liver and eliminated as NAM, a byproduct. (Liu, 2018)

Sublingual delivery solves the bioavailability problem

Molecules like NMN, NR and NAD+ that have low molecular weight and are hydrophilic can be absorbed through the capillaries under the tongue directly into the bloodstream. This is called sublingual delivery – under the tongue.

ALIVE BY SCIENCE was the first to create a sublingual NMN tablet for optimal absorption.

Sublingual Delivery can Bypass the Stomach and Liver.

This solves the bioavailability problem of capsules, which are degraded in the stomach. Sublingual delivery of the NAD+ compound enables it to be just as effective as NAD+ precursors.

This advanced absorption method allows NMN molecules to be delivered to cells and tissues intact for the first time, which increases systemic NAD+ levels.

More about Sublingual
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Why no sublingual NR?

Nicotinamide Riboside is not stable by itself so Chromadex and Elysium Health both add Chloride to make it stable. NR is  Nicotinamide Riboside with Chloride, making the taste unacceptable for sublingual use.

NR is only available in capsule form, which much pass through the stomach and liver where it is metabolized to the less effective Nicotinamide. (Liu, 2018) .

NAD+ SUPPLEMENTATION

Restores NAD+ in brain, Increases Metabolism
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Not limited by homeostasis
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NMN SUPPLEMENTATION

Blood Vessel Re-growth, Strength, Endurance
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NMN is stable in the bloodstream

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homeostasis uncertain
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Misc
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Clinical Studies
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NR SUPPLEMENTATION

NR is NOT STABLE and not found in blood plasma
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NR effective in liver short term
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NR limited by HOMEOSTASIS
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NMN SUPPLEMENTS

NAD+ SUPPLEMENTS

NAD+ OPTIMIZERS