Bioavailability Issues – ALIVE BY SCIENCE – Bioavailable NAD+ Boosters

BIOAVAILABILITY ISSUES WITH NAD+ PRECURSORS

When taken as oral supplements, NAD+ and its precursors are almost entirely degraded to Nicotinamide (NAM) in the stomach, intestines, and liver, greatly diminishing the effectiveness. (1,2,3,4,5)

Delivery methods that avoid digestion and deliver the product intact to cells throughout the body are needed to realize the potential of NAD+ Boosters. - more -

Research is clear that NAD+ and its precursors are almost entirely degraded to the less effective Nicotinamide (NAM) in the stomach, intestines and liver (1,2,3,4,5)

"Oral NR dosing increased circulating NAM ~40-fold while NMN remained unchanged and NR was detected only at trace levels in the blood. Thus, the majority of the orally administered NR that reaches the muscle appears to enter in the form of liberated NAM or as NMN" (6)

Quotes from some research below:

Unlike in cell culture where NR and NMN are readily incorporated into NAD, oral administration fails to deliver NR or NMN to tissues (4)

Interestingly, we found that neither compound was able to enter the circulation intact in substantial quantities when delivered orally (4)

Orally delivered NR and NMN are converted into NAM before reaching the systemic circulation. (4)

Delivery methods that bypass the gastrointestinal tract completely, or protect NAD+ metabolites are necessary.