Search found 175 matches

by AlbertY
Thu Feb 04, 2021 3:21 pm
Forum: NAD+
Topic: Healthy Lifestyle Recommendations: Do the Beneficial Effects Originate from NAD+ Amount at the Cellular Level?
Replies: 3
Views: 933

Healthy Lifestyle Recommendations: Do the Beneficial Effects Originate from NAD+ Amount at the Cellular Level?

I just found this nice review paper giving healthy lifestyle recommendations based on current knowledge on NAD. The best thing is that it is an open-access paper, no paywall!
https://www.hindawi.com/journals/omcl/2020/8819627/
by AlbertY
Mon Jan 25, 2021 10:15 am
Forum: Senolytics
Topic: Senolytics alleviates age-related cognitive impairment
Replies: 2
Views: 1412

Senolytics alleviates age-related cognitive impairment

This is the first paper showing that the removal of the senescent cell can alleviate brain inflammation and cognitive decline during aging. With AP20187 or with the senolytic cocktail Dasatinib and Quercetin, they observed that both strategies resulted in reduced senescent cell, microglial activatio...
by AlbertY
Tue Jan 19, 2021 1:27 pm
Forum: Renue NAD+ Skin Care
Topic: Flushing (or other side effects) with Renue?
Replies: 7
Views: 2277

Re: Flushing (or other side effects) with Renue?

Hi, flushing is a well-known side-effect of taking high dose of NAD precursor. It's harmless as long as it is due to NAD, instead of other ingredients in the product. It appears as a flush of red on the skin, which may be accompanied by an itching or burning sensation. Symptoms typically go away aft...
by AlbertY
Tue Jan 19, 2021 1:15 pm
Forum: NMN
Topic: NMN Sublingual vs. Oral
Replies: 4
Views: 1072

Re: NMN Sublingual vs. Oral

Hi Tim, welcome! in short: we don't know yet, but the sublingual is more promising than oral, based on current evidence. Full answer: As far as I know, there is currently no human study on sublingual NMN yet. However, there is a recently study shows that oral administration of NMN suffers from bacte...
by AlbertY
Fri Jan 15, 2021 2:39 pm
Forum: Senolytics
Topic: Fisetin as entry inhibitor in COVID19 infection
Replies: 4
Views: 1140

Fisetin as entry inhibitor in COVID19 infection

https://pubmed.ncbi.nlm.nih.gov/33382023/ TMPRSS2 is gateway for SARS CoV-2 entry into the host cell. It causes proteolytic activation of spike protein and discharge of the peptide into host cell. The TMPRSS2 inhibition could be one of the approaches to stop the viral entry. In this study, they fou...
by AlbertY
Wed Jan 06, 2021 8:58 pm
Forum: Senolytics
Topic: Fisetin Regulates Gut Microbiota and shows Neuroprotective Effect on Parkinson's Disease
Replies: 6
Views: 2263

Fisetin Regulates Gut Microbiota and shows Neuroprotective Effect on Parkinson's Disease

Impressive result! https://pubmed.ncbi.nlm.nih.gov/33381005/ Previous studies have reported the antioxidant, anti-inflammatory, and anti-cancer effects of fisetin. However, the therapeutic efficacy of fisetin in Parkinson's disease (PD) is unclear. In this study, researchers demonstrated that fiseti...
by AlbertY
Sun Jan 03, 2021 6:26 pm
Forum: NMN
Topic: NMN Cycling
Replies: 8
Views: 2733

Re: NMN Cycling

Hmmm, I think David does metformin cycling, like not taking it at the day of exercise, as it blocks the benefit of exercise. I'm also curious about the underlying reason for NMN cycling.
by AlbertY
Sun Jan 03, 2021 6:16 pm
Forum: NMN
Topic: Finally, there is a Toxicity Study of NMN
Replies: 3
Views: 1760

Finally, there is a Toxicity Study of NMN

There were many discussions on the dose of NMN one should take. And whether it is safe to take a high dose of NMN. I just found a toxicity study on NMN. https://pubmed.ncbi.nlm.nih.gov/33384603/ TLDR. NMN is safe (no huge side effect) even with a very high dose. In this paper, they gavaged the anima...
by AlbertY
Sun Jan 03, 2021 4:48 pm
Forum: Exercise
Topic: Exercise as senolytics
Replies: 9
Views: 3097

Exercise as senolytics

https://pbs.twimg.com/media/EqgV7YjXUAEbUdL?format=png&name=small https://onlinelibrary.wiley.com/doi/10.1111/acel.13294 This is a systemic review paper that found: Exercise can reduce the markers of senescent cells in healthy humans, while it lowered the markers of senescent cells in obese but not...
by AlbertY
Thu Dec 31, 2020 3:45 pm
Forum: NMN
Topic: Neuroprotective effect of NMN
Replies: 4
Views: 2272

Neuroprotective effect of NMN

A new study addressed the neuroprotective effect of NMN in a photoreceptor degenerative model (retinal detachment). They found that NMN increased NAD+ levels, SIRT1 protein expression, and heme oxygenase-1 (HO-1) expression. And NMN administration exerts neuroprotective effects on photoreceptors aft...