Search found 158 matches

by AlbertY
Fri Sep 18, 2020 12:53 pm
Forum: Longevity
Topic: A phone App that assess biological age
Replies: 0
Views: 28

A phone App that assess biological age

This might be interesting. Young.ai, an iPhone app created by Hong Kong–based technology company Deep Longevity, will use a variety of “biological clock” algorithms to compute a user’s biological age based on everything from blood samples and data collected from wearable fitness trackers to a simple...
by AlbertY
Sat Sep 05, 2020 3:29 pm
Forum: Senolytics
Topic: Fisetin Alleviates Hepatic and Adipocyte Fibrosis and Insulin Resistance in Diet-Induced Obese Mice
Replies: 0
Views: 165

Fisetin Alleviates Hepatic and Adipocyte Fibrosis and Insulin Resistance in Diet-Induced Obese Mice

A recent research! I remember someone asked about hepatic fibrosis months ago, and now we have some answer in this paper.  The present study aimed to investigate the protective role of the flavonoid fisetin (FI) on inflammation-mediated metabolic diseases, especially tissue fibrosis and insulin resi...
by AlbertY
Tue Sep 01, 2020 10:36 pm
Forum: Healthy Aging News and Research
Topic: Partial reprogramming reverse epigenetic age
Replies: 3
Views: 463

Re: Partial reprogramming reverse epigenetic age

Check this new paper on partial reprogramming! It's a proof of concept that partial reprogramming can safely reverse aging! Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12877 Induced pluripoten...
by AlbertY
Tue Aug 25, 2020 3:55 pm
Forum: Healthy Aging News and Research
Topic: Partial reprogramming reverse epigenetic age
Replies: 3
Views: 463

Partial reprogramming reverse epigenetic age

Check this new paper on partial reprogramming! It's a proof of concept that partial reprogramming can safely reverse aging! Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12877 Induced pluripotent...
by AlbertY
Sat Aug 15, 2020 5:14 pm
Forum: NMN
Topic: SS‐31 and NMN: Two paths to improve metabolism and function in aged hearts
Replies: 8
Views: 909

SS‐31 and NMN: Two paths to improve metabolism and function in aged hearts

A new research on NMN! NMN fully reversed an age‐related deficiency in systolic function. https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13213 The effects of two different mitochondrial‐targeted drugs, SS‐31 and NMN, were tested on Old mouse hearts. After treatment with the drugs, individuall...
by AlbertY
Fri Aug 07, 2020 4:35 pm
Forum: Healthy Aging News and Research
Topic: New Research on Aging and COVID-19
Replies: 2
Views: 870

New Research on Aging and COVID-19

https://www.medrxiv.org/content/10.1101/2020.08.06.20169854v1 "The genetic variation that leads to a longer lifespan is significantly associated with a lower risk of COVID-19 infection. The risk of been infected is decreased by 68% per additional 10 years of life." "At the phenotypic level, we appli...
by AlbertY
Tue Aug 04, 2020 3:36 pm
Forum: NMN
Topic: NMN Supplementation Reverses the Declining Quality of Aged Oocytes
Replies: 4
Views: 1382

NMN Supplementation Reverses the Declining Quality of Aged Oocytes

Another piece of evidence on the effect of NMN to oocyte quality! https://doi.org/10.1016/j.celrep.2020.107987 Key points: - NMN supplementation restores NAD+ levels in maternally aged oocytes - NMN increases the number of ovulated oocytes in aged mice - NMN enhances meiotic competency and fertiliza...
by AlbertY
Thu Jul 30, 2020 3:23 pm
Forum: NMN
Topic: Use bacteria to produce NMN
Replies: 2
Views: 1169

Use bacteria to produce NMN

This is an interesting study https://pubmed.ncbi.nlm.nih.gov/32718347/ They engineered Escherichia coli cells to biosynthesize the NMN, which has been efficiently used in cell-free biosynthesis. They explored various pathway combinations and host gene disruption to achieve an intracellular level of ...
by AlbertY
Thu Jul 30, 2020 3:16 pm
Forum: NMN
Topic: Dosage 1g is enough?
Replies: 15
Views: 3502

Re: Dosage 1g is enough?

Hello, I hope that you are all well. I’ve been doing some reading and went back to the original nmn mice article in cell. https://www.cell.com/cell/fulltext/S0092-8674(18)30152-1 “To restore NAD+ levels, we administered NMN to 18-month-old mice via drinking water for 2 months at 400 mg/kg/day” Plea...
by AlbertY
Mon Jul 20, 2020 11:28 pm
Forum: NMN
Topic: Dosage Sublingual Powder for Fertility
Replies: 7
Views: 2615

Re: Dosage Sublingual Powder for Fertility

Hi all, We have purchased the sublingual NMN powder after reading a couple studies about it’s potential for increased egg quality. My wife has had some stomach aches/cramps when taking. Can anyone advise on dosage? How many of the small scoops to take for fertility? Anyone here have experience? We’...