NAD+Nuchida Claim

ProudDaddy
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Joined: Thu Sep 19, 2019 7:51 am

Nuchida Claim

Post by ProudDaddy » Thu Sep 19, 2019 8:05 am

Nuchida is claiming that NAD is too large to enter a cell and that taking NAD+ by ANY route is therefore useless.

https://nuchido.com/blogs/articles/we-n ... a78acebbc0

My research indicates that this is not totally correct: Connexin 43 is a transporter for at least some cell types, and exogenous NAD is known to enter mitochondria.

Who is correct?


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nettlesbe
Site Admin
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Re: Nuchida Claim

Post by nettlesbe » Thu Sep 19, 2019 8:56 pm

You're right, NAD+ has been proven to enter some cells directly by Connexin43. Also some other routes.

https://alivebynature.com/exogenous-nad ... penditure/


The enzymes to metabolize it to NMN, NR, NAM and other products like very beneficial products like adenosine and ATP are ubiquitous in blood. Its true we don't know how much NAD+ goes where, by what route, but it is silly to imagine NAD+ in the bloodstream is trapped and not useful.

This is discussion of the research showing when injected in humans by IV, NAD+ and all metabolites totally dissapear for 2 hours, showing it is not trapped. It does show up in blood plasma later as NAD+, NAM, NMN, and MeNam in similar quantities, showing it is readily converted to other metabolites.


viewtopic.php?f=4&t=754&fbclid=IwAR3ww3 ... 2kF1qJoe40
Drdavid
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Joined: Thu Aug 15, 2019 9:59 am

Re: Nuchida Claim

Post by Drdavid » Thu Sep 19, 2019 9:54 pm

Thank you for providing the research.
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