NutritionDepleted Methyl Groups and advanced age

NewLifeScience
Posts: 334
Joined: Thu Aug 22, 2019 4:17 pm

Re: Depleted Methyl Groups and advanced age

Post by NewLifeScience » Thu Aug 27, 2020 8:39 am

ssslyr wrote:
Wed Aug 26, 2020 8:43 pm
Yes i was asking why I'd want to use both methylcobalamin and adenosylcobalamin.
Ah. Because bodies need both forms, and the ability to convert between them is both variable and may degrade with age. I recommend MeCbl daily. AdCbl gets stored in the liver and doesn't need as frequent replenishment. AdCbl is available in sublingual tabs only, unless you have seriously good connections. :)

You might be surprised at the difference (native, bioavailable) B12 can make. I've had people rush up to me in gratitude for changing their lives--from B12.
 
 

 
Very interesting.

I think I will try this with my mother. She has ongoing fatigue and it has gotten far worse since a bout of pneumonia 2 years ago.

This would be so awesome if it helps. I will follow up on this.
 


Taking:
Liposomal Curcumin / Resveratrol
NMN 500mg
Melatonin 1mg (am)
Blueberry extract 1g
Berberine 250mg
Vitamin E tocotrienols 50 mg
Astragalus 500 mg
Methyl B12 5000 mcg 3x/week
Methyl Folate 1000 mcg 1-3/week
canadahealthy
Posts: 270
Joined: Tue Aug 20, 2019 5:31 pm

Re: Depleted Methyl Groups and advanced age

Post by canadahealthy » Fri Aug 28, 2020 6:17 pm

I agree that this is very interesting.

This forum is an extremely rare gem of knowledge, I really appreciate being a part of it, as a lay person.

Anything to improve the lives of our aging relatives.

If I notice anything, I will report back.
smokinjoe
Posts: 111
Joined: Sun Sep 01, 2019 9:24 am

Re: Depleted Methyl Groups and advanced age

Post by smokinjoe » Sat Aug 29, 2020 10:22 am

So I have also read on here where too much NMN can lead to depleted methyl groups. So it may follow that if we want to consider carefully how much NMN is given to someone who is elderly, especially if they suffer from frailty.

I recall my grandfather getting B12 shots, decades ago. So that makes me think it is an issue with elderly, as  i have heard this is something a lot of elderly people would get occasionally from their Family Doctors.

Lots of good information and discussion on this forum. :)
jessicaP
Posts: 57
Joined: Sun Nov 03, 2019 10:52 am

Re: Depleted Methyl Groups and advanced age

Post by jessicaP » Sat Sep 19, 2020 1:52 pm

so this stuff is very  inexpensive as we don't have to use it all the time, and it may be good to have it around if you are feeling fatigue - since my experience with NMN is the very opposite of fatigue, and also the experience of most of us here.

So it would be handy to have that particular derivative of B12 and methylfolate around.

 
NewLifeScience
Posts: 334
Joined: Thu Aug 22, 2019 4:17 pm

Re: Depleted Methyl Groups and advanced age

Post by NewLifeScience » Thu Oct 01, 2020 10:34 am

Well this is good information that i have already acted on.

I don't know if I feel any different. We had a family thing that was really tough in February... but my mental energy is improved.

I also give an elderly parent NMN, so I will add in these 2 supplements to support this process.
Taking:
Liposomal Curcumin / Resveratrol
NMN 500mg
Melatonin 1mg (am)
Blueberry extract 1g
Berberine 250mg
Vitamin E tocotrienols 50 mg
Astragalus 500 mg
Methyl B12 5000 mcg 3x/week
Methyl Folate 1000 mcg 1-3/week
JamesD
Posts: 10
Joined: Sun Nov 17, 2019 8:25 pm

Re: Depleted Methyl Groups and advanced age

Post by JamesD » Fri Oct 02, 2020 3:13 pm

I am still highly suspicious that taking NMN and NAD+ blew my entire nervous system last year. I developed severe insomnia and panic attacks after weeks of taking both NMN and NAD+. I also have the homogenous MTHFR gene mutation which makes me very bad at methylating in the first place. Can't help but wonder if I depleted my methyl groups to the point I ruined my health over this supplement. I wish I had more answers. 
 
CeeJayBee
Posts: 144
Joined: Thu Aug 22, 2019 4:19 pm

Re: Depleted Methyl Groups and advanced age

Post by CeeJayBee » Wed Oct 14, 2020 8:01 pm

JamesD wrote:
Fri Oct 02, 2020 3:13 pm
I am still highly suspicious that taking NMN and NAD+ blew my entire nervous system last year. I developed severe insomnia and panic attacks after weeks of taking both NMN and NAD+. I also have the homogenous MTHFR gene mutation which makes me very bad at methylating in the first place. Can't help but wonder if I depleted my methyl groups to the point I ruined my health over this supplement. I wish I had more answers. 
 


 
Have you tried Vitamin B12 and Follate?

i don't know much about this mutation... but from what i know about NMN or NAD+ the effects would eventually wear off after one stops taking them (which of course is why i don't).

What else was going on in the past year?

I am not a doctor but there are several hear who may be able to help you sort this out.
ChrisBON
Posts: 73
Joined: Mon Sep 16, 2019 6:09 pm

Re: Depleted Methyl Groups and advanced age

Post by ChrisBON » Thu Oct 29, 2020 6:24 pm

Well i am glad I asked about this, as I have been giving an elderly parent NMN for 7 months now.

I notice she walks more upright and complains of exhaustion a bit less. She is 85, so this is very good.

I also give her the B12 and Folate derivatives, so I don't have to worry about burning those methyl groups.

We are also working on removing a stressful situation from the equation and then i may be able to report better gains. Time will tell.
Taking:
NMN since June, 2019 (started at 250mg, 500mg as of Oct 1st)
NAD+ nasal spray since July, 2019
Resveratrol since Sept 2019
Astaxanthin 10mg since October 20th
Blueberry concentrate 500 mg since October 20th
Berberine 250 mg since October 20th
canadahealthy
Posts: 270
Joined: Tue Aug 20, 2019 5:31 pm

Re: Depleted Methyl Groups and advanced age

Post by canadahealthy » Fri Oct 30, 2020 6:04 pm

ChrisBON wrote:
Thu Oct 29, 2020 6:24 pm
Well i am glad I asked about this, as I have been giving an elderly parent NMN for 7 months now.

I notice she walks more upright and complains of exhaustion a bit less. She is 85, so this is very good.

I also give her the B12 and Folate derivatives, so I don't have to worry about burning those methyl groups.

We are also working on removing a stressful situation from the equation and then i may be able to report better gains. Time will tell.

 
What do you think of Fisetin? I am thinking of the 2 days one 26 days off. Would you think it is safe to try for a few months?
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