Healthy Aging News and ResearchWhen does aging begin? This research might give us anwser

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AlbertY
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When does aging begin? This research might give us anwser

Post by AlbertY » Thu Jan 02, 2020 6:22 am

An increase in the probability of death has been a defining feature of aging, yet human perinatal mortality starts high and decreases with age. Previous evolutionary models suggested that organismal aging begins after the onset of reproduction. However, we find that mortality and incidence of diseases associated with aging follow a U-shaped curve with the minimum before puberty, whereas quantitative biomarkers of aging, including somatic mutations and DNA methylation, do not, revealing that aging starts early but is masked by early-life mortality. Moreover, our genetic analyses point to the contribution of damaging mutations to early mortality. We propose that mortality patterns are governed, in part, by negative selection against damaging mutations in early life, manifesting after the corresponding genes are first expressed. Deconvolution of mortality patterns suggests that deleterious changes rather than mortality are the defining characteristic of aging and that aging begins in very early life.

In short, the aging process might start earlier than we thought.
https://linkinghub.elsevier.com/retriev ... 471931589X

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Ph.D. student at Harvard Medical School, doing research on aging
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AlbertY
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Re: When does aging begin? This research might give us anwser

Post by AlbertY » Thu Jan 02, 2020 6:24 am

And the methylation clock starts ticking when we were embryos
Ph.D. student at Harvard Medical School, doing research on aging
rhett
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Re: When does aging begin? This research might give us anwser

Post by rhett » Thu Jan 02, 2020 11:30 am

In theory, if you cleared off 100% of epigenetic information would you you turn into a big embryo?
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jocko6889
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Re: When does aging begin? This research might give us anwser

Post by jocko6889 » Fri Jan 03, 2020 11:02 pm

rhett wrote:
Thu Jan 02, 2020 11:30 am
In theory, if you cleared off 100% of epigenetic information would you you turn into a big embryo?
Zero epigenetic markers would make it an undifferentiated cell, also known as a stem cell. If aging is the "accumulation of methylation", then some aging is necessary in order for an egg to become differentiated into all component parts of the body. Too much methylation because of time, smoking, sun, x-rays, etc becomes the problem and is one fundamental cause of age.

According to Sinclair, there is an early snapshot of the young epigenome somewhere in the epigenome itself in every cell in our body, similar to a backup copy of a hard drive we make when we first buy a computer. In his experiments, this young epigenome is the focal point for communication with Yamanaka genes used to guide the reversal of accumulated methylation back to an earlier point in time. This has already been achieved by Sinclair in the optic nerves of mice and is one reason for growing optimism that age reversal will be accomplished sooner than anyone could have possibly imagined.
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