Loss of circulation to skeletal muscles causing weakness and frailty are one of the major signs of aging. In a recent study published in Nature, Urolithin A (UA), a compound known to improve muscle function was administered to aging mice for a period of 12-16 weeks.
At the end of the study, ATP and NAD+ levels were measured in vivo and shown to have significantly increased in mouse skeletal muscle, bolstering SIRT1 levels and upregulating angiogenic pathways.
"Nutritional supplements are commonly used by athletes with the intent of obtaining ergonic benefits. While whether there is a direct cause and effect relationship between nutritional supplements and exercise performance remains under consideration, the evidence supporting that such supplements may augment mechanisms supporting skeletal muscle health and function is compelling.
Both geriatric and sedentary populations in the United States heavily rely on nutritional supplements for maintenance of health and fitness. Maintenance of and development of skeletal muscle health is of specific interest to the aging population who face the threat of sarcopenia.
Age-related decline in skeletal muscle vascular health is of significance concern in this regard. Nutritional supplements are known to improve muscle macro and microcirculation".
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