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NMN for cognition and reduced fear/anxiety

Posted: Sat Nov 16, 2019 12:50 am
by Fred
In this recent study NMN reduced anxiety/fear in aged genetically engineered mice:
In our present study, we found that older mice developed a cognitive hypersensitivity following exposure to certain aversive environmental stimuli, possibly reflecting age-related alterations in emotionality (fear and/or anxiety) and sensory processing.

Interestingly, NMN supplementation to old mice was able to mitigate age-associated cognitive hypersensitivity and age-associated increases in shock sensitivity, raising the possibility that modifications in the NMN supplementation procedure (e.g., extended treatment duration) might lead to greater positive effects concerning the putative emotionality component of the age-related hypersensitivity as well.
In conclusion, our study demonstrates that age-associated alteration in cognitive and behavioral functions is induced by reduced NAMPT-mediated NAD+ biosynthesis in the hippocampus, particularly in the CA1 region, in old mice.

Our study also shows that NMN supplementation, even in the short term, is able to mitigate the age-associated alteration in the sensory processing of some aversive stimuli and possibly other related behaviors.

Although further detailed analyses will be necessary, our findings provide critical insights into how aging affects cognitive and behavioral functions and how such impairments can be prevented or treated to enhance the quality of our later lives.
"Nampt knockdown recapitulates hippocampal cognitive phenotypes in old mice which nicotinamide mononucleotide improves"
https://www.nature.com/articles/s41514-018-0029-z

Re: NMN for cognition and reduced fear/anxiety

Posted: Sat Nov 16, 2019 11:01 am
by NewLifeScience
To me, anxiety is the inflammation of the brain and body in a general sense, and the cortisol and catecholamines that end up in our blood and tissues can cause great damage to our bodies.

It is another reason i run. The good hormones released during a good run essentially wash our blood of the bad ones.

I can't cite any references off hand, but i did research this several years ago.

Another great reason for running, especially if you are dealing with anxiety and that you are essentially responding to the fight or flight response, and are choosing flight, thereby allowing the brain to process stress better since it isn't locked in the conflict (i.e. not choosing fight or flight)

Re: NMN for cognition and reduced fear/anxiety

Posted: Sun Nov 17, 2019 8:19 pm
by Drdavid
Fred wrote:
Sat Nov 16, 2019 12:50 am
In this recent study NMN reduced anxiety/fear in aged genetically engineered mice:
In our present study, we found that older mice developed a cognitive hypersensitivity following exposure to certain aversive environmental stimuli, possibly reflecting age-related alterations in emotionality (fear and/or anxiety) and sensory processing.

Interestingly, NMN supplementation to old mice was able to mitigate age-associated cognitive hypersensitivity and age-associated increases in shock sensitivity, raising the possibility that modifications in the NMN supplementation procedure (e.g., extended treatment duration) might lead to greater positive effects concerning the putative emotionality component of the age-related hypersensitivity as well.
In conclusion, our study demonstrates that age-associated alteration in cognitive and behavioral functions is induced by reduced NAMPT-mediated NAD+ biosynthesis in the hippocampus, particularly in the CA1 region, in old mice.

Our study also shows that NMN supplementation, even in the short term, is able to mitigate the age-associated alteration in the sensory processing of some aversive stimuli and possibly other related behaviors.

Although further detailed analyses will be necessary, our findings provide critical insights into how aging affects cognitive and behavioral functions and how such impairments can be prevented or treated to enhance the quality of our later lives.
"Nampt knockdown recapitulates hippocampal cognitive phenotypes in old mice which nicotinamide mononucleotide improves"
https://www.nature.com/articles/s41514-018-0029-z
Since this study showed action within the CA1 region of the hippocampus are we thinking that NMN could be a potential therapy for anxiety? It appears that it was in rats.

Re: NMN for cognition and reduced fear/anxiety

Posted: Sun Nov 17, 2019 10:39 pm
by Fred
Drdavid wrote:
Sun Nov 17, 2019 8:19 pm

Since this study showed action within the CA1 region of the hippocampus are we thinking that NMN could be a potential therapy for anxiety? It appears that it was in rats.
That was my interpretation but they never mention "anxiolytic" effect so maybe "age-related hypersensitivity" is something else. But to me it can only translate to fear/worrying/anxiety in humans.

Re: NMN for cognition and reduced fear/anxiety

Posted: Tue Nov 19, 2019 1:48 am
by AUKC
Personally I can't say i've felt any anxiety while on NMN. Generally there may be a bit of stress/work related anxiety, and even so, none that I can remember recently now.

Re: NMN for cognition and reduced fear/anxiety

Posted: Tue Nov 19, 2019 7:09 am
by Drdavid
Fred wrote:
Sun Nov 17, 2019 10:39 pm
Drdavid wrote:
Sun Nov 17, 2019 8:19 pm

Since this study showed action within the CA1 region of the hippocampus are we thinking that NMN could be a potential therapy for anxiety? It appears that it was in rats.
That was my interpretation but they never mention "anxiolytic" effect so maybe "age-related hypersensitivity" is something else. But to me it can only translate to fear/worrying/anxiety in humans.
I agree Fred, I was surprised the "anxiolytic" effect was never used. I hope further research is coming soon in a human trial regarding this very issue.