NMNDosage Questions

OrionEridanus
Posts: 1
Joined: Wed Feb 10, 2021 1:47 pm

Dosage Questions

Post by OrionEridanus » Wed Feb 10, 2021 6:49 pm

I read some of the papers referred to on the NMN page. There were two mouse experiments mentioned.  

In one Cell paper ( https://www.cell.com/cell/pdf/S0092-8674(18)30152-1.pdf ), mice were given doses of NMN of 400 mg/kg/day.  A 65 kg human would need to ingest 26g per day. 

In another Cell paper https://www.cell.com/cell-reports/fullt ... all%3Dtrue the low dose mice were given water at 0.5 g/l .  An average adult mouse consumes about 4 ml/water per day ( http://web.jhu.edu/animalcare/procedures/mouse.html )   and weighs about 26 g so that works out to 76 mg/kg/day --->  5 g/day for a 65 kg adult human.  

This product contains 75 240 mg doses.   26 g would require ingesting 3.6 bottles of this product daily. 5 g would require 3/4 of a bottle per day. Is there something I am misunderstanding when I try to draw a line from the studies to the dose recommended on the product page? If the difference is better delivery using liposomes, is there a paper that points to significant improvement in blood plasma or intracellular concentration when ingested this way?

Thanks
 
 


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jocko6889
Posts: 304
Joined: Tue Jul 23, 2019 11:35 pm
Location: Tulsa, OK

Re: Dosage Questions

Post by jocko6889 » Thu Feb 11, 2021 4:26 pm

OrionEridanus wrote:
Wed Feb 10, 2021 6:49 pm
I read some of the papers referred to on the NMN page. There were two mouse experiments mentioned.  

In one Cell paper ( https://www.cell.com/cell/pdf/S0092-8674(18)30152-1.pdf ), mice were given doses of NMN of 400 mg/kg/day.  A 65 kg human would need to ingest 26g per day. 

In another Cell paper https://www.cell.com/cell-reports/fullt ... all%3Dtrue the low dose mice were given water at 0.5 g/l .  An average adult mouse consumes about 4 ml/water per day ( http://web.jhu.edu/animalcare/procedures/mouse.html )   and weighs about 26 g so that works out to 76 mg/kg/day --->  5 g/day for a 65 kg adult human.  

This product contains 75 240 mg doses.   26 g would require ingesting 3.6 bottles of this product daily. 5 g would require 3/4 of a bottle per day. Is there something I am misunderstanding when I try to draw a line from the studies to the dose recommended on the product page? If the difference is better delivery using liposomes, is there a paper that points to significant improvement in blood plasma or intracellular concentration when ingested this way?

Thanks
 
 


 
It looks like you are multiplying weight to calculate human dose.  Calculating mouse to human dosage is very complicated.  Mice have a much faster metabolism, so it's a common error to simply use difference in weight to figure human dose.  In reality, the human dose would be much less than what you came up with.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804402/
 
 
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