The most effective seems to be hydroxycitrate, aspirin, resveratrol and spermidine. Worth a read!
https://sci-hub.se/10.1016/j.cmet.2019.01.018The permanent or periodic reduction of calorie intake without malnutrition (caloric restriction and fasting) is the only strategy that reliably extends healthspan in mammals including non-human primates.
However, the strict and life-long compliance with these regimens is difﬁcult, which has promoted the emergence of caloric restriction mimetics (CRMs).
We deﬁne CRMs as compounds that ignite the protective pathways of caloric restriction by promoting autophagy, a cytoplasmic recycling mechanism, via a reduction in protein acetylation.
Here, we describe the current knowledge on molecular, cellular, and organismal effects of known and putative CRMs in mice and humans. We anticipate that CRMs will become part of the pharmacological armamentarium against aging and age-related cardiovascular, neurodegenerative, and malignant diseases.