https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980558/3.4. Diet-derived natural products
Increasing studies have demonstrated that some diet-derived natural products, including curcumin, resveratrol, epigallocatechin gallate (EGCG), genistein, 3, 3-diindolylmethane (DIM) and caffeine, may inhibit mTOR signaling directly or indirectly (Table 1) [140-147].
EGCG, the most studied polyphenol component in green tea, is a potent antioxidant that may have therapeutic potential for many disorders including cancer. In the co-cultured keloid fibroblasts and HMC-1 cells, EGCG treatment dose-dependently reduced the increased phosphorylation of Akt, S6K and 4E-BP1 . In both p53 positive and negative human hepatoma cells, EGCG activated AMPK, resulting in the suppression of downstream substrates, including mTOR and 4E-BP1, and a general decrease of mRNA translation .
Resveratrol is a polyphenolic flavonoid from grapes and red wine with potential anti-inflammatory, antioxidant, neuroprotective and anticancer properties . In human U251 glioma cells, resveratrol downregulated PI3K/Akt/mTOR-mediated signaling pathway, and combination with rapamycin enhanced resveratrol-induced cell death . In smooth muscle cells (SMC), resveratrol inhibited the proatherogenic oxidized LDL-induced activation of the PI3K/Akt/mTOR/S6K pathway and remarkably suppressed DNA synthesis and proliferation of SMC . Recently it has been described that resveratrol activated AMPK in both ER-positive and ER-negative breast cancer cells, and consequently inhibited mTOR and its downstream 4E-BP1 signaling and mRNA translation. It was also found that the activation of AMPK by resveratrol was due to the induction of Sirtuin type 1 (SIRT1) expression in ER-positive breast cancer cells .
Increasing evidence suggested that curcumin may exert its antiproliferative effects by inhibiting mTOR signaling and thus may represent a new class of mTOR inhibitor. Curcumin is a polyphenol natural product isolated from the rhizome of the plant Curcuma longa and is undergoing early clinical trials as a novel anticancer agent . Numerous studies have shown that curcumin inhibited the growth of a variety of cancer cells and showed effectiveness as a chemopreventive agent in animal models of carcinogenesis [152,153]. In our studies, we showed that curcumin inhibited cell growth, induced apoptosis and inhibited the basal or IGF-I-induced motility of rhabdomyosarcoma cells . In numerous cancer cell lines, curcumin inhibited phosphorylation of mTOR and its downstream targets, S6K1 and 4E-BP1, suggesting that curcumin may execute its anticancer effect primarily through blocking mTOR mediated signaling pathways [153,154]. Most recently, we further found that curcumin was able to dissociate raptor from mTOR, leading to inhibition of mTORC1 activity .
I’m also a big fan of Turmeric and have been for a long time utilising it daily for it’s potent anti inflammatory properties along with its potential ability to help in the never ending fight against cancer.
I take a minimum of 2 heaped teaspoons of a product called Turmerix which has a combination of many beneficial herbs and black pepper, all added to its formula. It uses Turmeric grown in the Kerala region of India and has approximately 6% of Curcumin, one of the main active ingredients.
Other brands only seem to have about about 3%.
Another product to help keep inflammation at bay which as we know, is a precursor to many diseases..
Thank you Newage. We have that product in Sweden too but regular ecological turmeric from the supermarket contains 6% curcumin and costs $2 and 4 cents for a small jar.Newage wrote: ↑Thu Sep 19, 2019 4:40 pmI take a minimum of 2 heaped teaspoons of a product called Turmerix which has a combination of many beneficial herbs and black pepper, all added to its formula. It uses Turmeric grown in the Kerala region of India and has approximately 6% of Curcumin, one of the main active ingredients.
Other brands only seem to have about about 3%.
Turmerix contains only 60% turmeric by weight so it´s an extremely costly way to get curcumin. Not saying the product is bad, at all. But I´ll keep my supermarket turmeric with 6% curcumin in the pantry for now.
I might just move to Sweden.
I've tried turmeric lattes and teas as another way to incorporate turmeric into my daily nutrition, but I didn't find them to be very tasty at all, so I've just stuck to putting turmeric into curries.
For those curious, this was the tea that I tried:
https://www.higherlivingherbs.com/all-t ... n-turmeric
It was at various coffee shops that I've tried turmeric lattes (all of which made me go, "hmmm, time to order a regular latte!"), but here's a recipe I found to make your own turmeric latte at home (I might give it a go, seems alright, actually!):
possibly enhance longevity.
https://www.washingtonpost.com/business ... tudy-says/
https://www.sciencedirect.com/science/a ... via%3Dihub
Both articles on lead levels in Turmeric are very informative and above all “ very scary”..
Goes to show “ the hidden additives in some imported products, just when you think you are on a winner.”