NMN is most effective at restoring intracellular NAD+

This new research examines what happens to NR, NMN and other metabolites of NAD+ in the bloodstream and how they effect intracellular NAD+ levels in peripheral tissues. Degradation of Extracellular NAD+ Intermediates in Cultures of Human HEK293 Cells(Nikiforov, [...]

NAD+ is the Transport Molecule Used by the Body, Not Nicotinamide Riboside

Restoring NAD+ levels in older animals and humans is at the center of efforts to slow or even stop the effects of aging. One method being researched is providing supplements  such as Nicotinamide Riboside (NR) that the body [...]

Bacteria in Gastrointestional Tract Metabolize NMN and Impact NAD+ Metabolome

This recently published research by Drs. Lindsay Wu, David Sinclair and others examined the pathways that oral NMN takes to becoming NAD+ in mice. It confirmed some aspects of earlier research, and also made some surprising new findings. [...]

Small Dose of NMN Restores Fertility in Old Mice, Large Dose Does Not – Implications for Dosage Suggestions

Recently published research shows that a small dose of NMN in the drinking water was able to improve the quality of eggs in older mice and reverse infertility. Researchers at the Universities of Queensland and New South Wales  [...]

Justin Bieber gets weekly IV drips of NAD+

  Justin Bieber gets weekly IV drips of NAD+ to help with the effects of his years of substance abuse   Justin Bieber opened up about his substance abuse, mental health, and recovery process on his new YouTube [...]

Sublingual delivery of NAD+ boosters

[...]

NAD+ for Metabolism and Brain, NMN for the body?

Do NMN and NAD⁺ have different effects on the body? Researchers use supplementation with NMN, NR and NAD⁺ to restore levels of NAD⁺ in mice, making them look and behave like they did when young and extending their [...]

What is NAD+?

Poor Bioavailability from Capsules NAD+ not effective in drinking water or in capsule form The NAD+ molecule is twice as large as NR or NMN, and is totally degraded in the gastrointestinal tract, so researchers do not use [...]

LSG – Liposomal Sublingual Gel – New delivery method

  LSG – combining the power of Liposomes & Sublingual delivery in our advanced Gel technology Liposomal Sublingual Gel (LSG™) is a novel nanoliposomal nutrient delivery system that utilizes pharmaceutical grade organic, non-GMO phospholipids designed to deliver unmetabolized [...]

How Long Does Our NMN Retain Its Potency?

In a recent podcast, Dr. David Sinclair stated that NMN found at room temperature, “…not in a stabilized form… will degrade into nicotinamide.” While this applies to the form of NMN used by Dr. Sinclair’s lab and that [...]

How NAD+ Boosts ATP and What it Means for Health and Aging

Much of the attention on the benefits of restoring NAD+ levels focus on its role in activating sirtuins. However, scientific research shows that NAD supplementation has a clear beneficial effect not only on ageing itself but also on [...]

NAD⁺ Injection Restores NAD⁺ Levels in Brain and Cognition in Mice

In a recent study, 18 male APP/PS1 mice were intraperitoneally injected with 30 mg/kg NAD⁺ at 20 weeks of age and once every other day for 4 weeks. These transgenic mice were used as they develop the behavioral [...]

1st NMN Human Study Demonstrates Safety and Faster Utilization than NR

The first study of NMN in humans was just published. https://www.jstage.jst.go.jp/…/advpub_EJ19-03…/_pdf/-char/en This japanese study looked at a single dose of 100, 250, or 500 mg NMN capsules to 10 men 40-60 years old. No adverse effects were noted. [...]

NAD+ IV increases NAD+ levels in blood plasma 400% in humans

This study was just published that documented changes in plasma and urine levels of NAD+ and its metabolites during and after 750 mg NAD+ intravenous (IV) infusion. A Pilot Study Investigating Changes in the Human Plasma and Urine [...]

NMN Improves Cerebrovascular Function and Cognition in Mice

Decreased NAD+ levels are implicated in a wide range of age related impairments. There is  evidence that restoring NAD+ by treatment with nicotinamide mononucleotide (NMN) may reverse age-related dysfunction in multiple organs. For instance, prior research showed supplementation [...]

Slc12a8 does not solve the bioavailability problem for NMN Capsules

This research was published in January 2019 that found an enzyme named Slc12a8 that can transport a small quantity of Nicotinamide Mononucleotide (NMN) directly into some cells. However, this enzyme is only prevalent in the small intestine of [...]

Increased NAD+ in Bloodstream of Nursing Mice Results in Healthier, Stronger, Smarter Offspring

This study fed lactating mice Nicotinamide Riboside (NR) in chow for 21 days after birth of offspring to measure the effect on the health of their pups who did not receive any NR. After 21 days, the pups [...]

1 Comment

Scientists discover pathway used by NMN to restore NAD+ levels

Yes, NMN can cross the cell membrane intact This research was just published that found an enzyme named Slc12a8 that can transport a small quantity of Nicotinamide Mononucleotide (NMN) directly into some cells However, this enzyme is only [...]

Fisetin – A Powerful Senolytic that Extends Health and Lifespan

    LSG Fisetin Solves the Bioavailability Problem Fisetin has poor bioavailability when taken orally. Studies show Liposomal Fisetin is up to 27x more bioavailable, which allows smaller dosages that put less strain on the liver. 3 Our [...]

Tru Niagen vs Basis

As you’re reading this, there are mind-boggling advances being made in longevity and anti-aging. In fact, just a couple of years ago, scientists were able to reverse the age of mice by up to 40 years simply by [...]

1 Comment

Exogenous NAD+ Increases Metabolism

Effects of Chronic NAD Supplementation on Energy Metabolism and Diurnal Rhythm in Obese Mice In a study published in 2018, scientists gave obese mice 1 mg/kg of NAD+ by inter peritoneal injection for 4 weeks, which  restored NAD+ levels [...]

NAD+ Supplements Regulate Energy Metabolism via the Hypothalamus

Exogenous nicotinamide adenine dinucleotide regulates energy metabolism via hypothalamic Connexin 43. There are some very important findings coming out of this research: Exogenous NAD+ definitely does cross the blood brain barrier through the Connexin 43 gap junction Exogenous [...]

NAD+ Supplements – Research and Benefits

Nicotinamide Adenide Dinucleotide (NAD+) and its immediate precursor Nicotinamide Mononucleotide (NMN) have both been shown to quickly elevate levels of NAD+ in various tissues and organs throughout the body. [...]

NMN product shows increased endurance and new blood vessel growth in mice

This new research, published March 22 in Cell, identifies the key cellular mechanisms behind vascular aging and the key role it plays on muscle health. Scientists at Harvard Medical School, Massachusetts Institute of Technology (MIT) and the University of [...]

NMN or NR

As we age, our levels of the Co-enzyme Nicotinamide Adenine Dinucleotide NAD+ drop significantl ≥NAD+ decrease is described as a trigger in age-associated decline(23), and perhaps even the key factor in why we age (5). In 2013, research published [...]