Do NMN and NAD⁺ have different effects on the body?
Researchers use supplementation with NMN, NR and NAD⁺ to restore levels of NAD⁺ in mice, making them look and behave like they did when young and extending their lifespan.
Although they have similar effect in some organs, there may be differences in the effect they have in other tissues throughout the body.
NAD⁺ in IV or IP injections
Research has been successful using NAD⁺ injections in mice.
In humans, clinics that provide NAD⁺ by IV are exploding in popularity, even though they charge over $1,000 a day and require the patient to be hooked up to a drip IV for 8 hours.
NMN and NR poor bioavailability in capsules
NMN and NR capsules are only partially digested in the stomach, but are almost totally metabolized in the liver and excreted as NAM (Liu, 2018).
Sublingual delivery solves the bioavailability problem
Molecules like NMN, NR and NAD⁺ that have low molecular weight and are hydrophilic can be absorbed through the capillaries under the tongue directly into the bloodstream. This is called Sublingual (under the tongue) delivery.
Ketosis is a metabolic state in which fat provides most of the fuel for the body. It occurs when there is limited access to glucose (blood sugar), which is the preferred fuel source for many cells in the body.
Ketosis can occur in many different diet plans whenever carb intake is low, but is most often associated the Ketogenic Diet, as that is a much easier method for restricting carbs (3, 4, 5, 6).
The Red bars in the chart at left show the increased levels of the Ketone Body BHB produced from a cyclical Keto diet, resulting in Increased NAD+ and greatly improved neurological function and health.
Sublingual delivery may help NAD+ metabolites and precursors avoid digestion in the stomach and liver.
NAD+ clinics use slow drip IV of NAD+ to avoid the stomach and liver. They are exploding in popularity, but the extreme cost and time required for treatment severely limit their application for the general public.
Sublingual NAD+ delivery may help solve the bioavailability problem and mimics the slow drip delivery used successfully by NAD+ IV clinics.
We believe the ability of NAD+ to increase metabolism through the hypothalamus has a great impact on the entire body.