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DECREASING INFLAMMATION INCREASES NAD+ AND IS KEY TO HEALTHY AGING

Results from hundreds of tests for Intracellular NAD+ levels tell us that those with high inflammation levels (measured by HS-CRP) have less success raising NAD+ levels.

Lowering inflammation can help restore NAD+ levels on their own, and also allow NAD+ precursors to work even better.

By lowering inflammation along with use of effective NAD+ precursors, we have seen increases of 300% in some subjects vs 50% with NAD+ precursors alone.

AMPK ACTIVATOR

 

Stimulating internal AMPK production helps restore and improve NAD+ levels. Fisetin, Epigallocatechin gallate (EGCG), Pterostilbene, Astragaloside IV and Ellagic Acid - offer AMPK & NAD+ support, anti-inflammatory and antioxidant benefits.

WHY IT'S IMPORTANT

NAD+ levels decline due to chronic inflammation and by prolonged oxidative stress. This causes a reduction in NAMPT and NAD+ levels in multiple tissues. NAD+ is constantly being created and consumed, and lower levels contribute to multiple health issues. Providing support by stimulating internal AMPK production will help increase NAD+ production.

STUDIES HAVE SHOWN

AMPK

AMPK is an important enzyme which senses energy levels (ATP) in the mitochondria. When energy is low, AMPK signals NAMPT to create more NAD+. The December 2011 e-publication AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network makes the point that AMPK plays a key role in controlling the aging process.

“Efficient control of energy metabolic homeostasis, enhanced stress resistance, and qualified cellular housekeeping are the hallmarks of improved healthspan and extended lifespan. AMPK signaling is involved in the regulation of all these characteristics via an integrated signaling network.”

FISETIN

Fisetin’s ability to clear out senescent cells has been shown to calm inflammation, improve physical function and increase lifespan in animals.(16) It’s benefits in studies are vast: from improved metabolic function and blood sugar levels, pain reduction, lowered cholesterol levels and blood pressure, while improving bone density.

EGCG

Epigallocatechin gallate (EGCG) is a unique plant compound that helps reduce inflammation, support heart health, optimal blood pressure and cholesterol levels. Early research suggests it may play a role in improving neurological function and protect against brain diseases.

PTEROSTILBENE

Pterostilbene has been shown to demonstrate preventative and therapeutic health benefits. Pterostilbene, which is structurally similar to resveratrol, reduces oxidative stress and production of reactive oxygen species, which are implicated in numerous disease processes.(17)

ASTRAGOLOSIDE IV

Astragaloside IV has strong antioxidant, anti-inflammatory, anti-apoptosis properties and numerous studies have shown it’s beneficial for brain health. In one study, it was found to enhance adult hippocampal neurogenesis, or the ability of the brain to increase neurons in the hippocampus (18). This process is very important for learning and memory as you age.

ELLAGIC ACID

Ellagic acid is associated with numerous health benefits from protecting brain function to lowering inflammation levels. Some animal and human studies suggest it may be useful in the treatment and prevention of age-related conditions, such as: type 2 diabetes, and neurodegenerative brain diseases. (19,20)

  • Benefits: NAD+ support, Immune Support, Metabolic Health, Neurological Health, Cardiovascular Support

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APIGENIN

LIPO Apigenin - Alive By Science Apigenin is a powerhouse anti-aging compound, offering antioxidant, anti-inflammatory, antiviral, and neuroprotective properties, while boosting NAD+ levels, diminishing oxidative stress and improving cellular detoxification.

WHY IT'S IMPORTANT

As people get older, it becomes more difficult for the body to maintain proper energy production, mitochondrial function & repair mechanisms. Nicotinamide adenine dinucleotide (NAD+) is a molecule that is crucial for maintaining mitochondrial health and energy production and it diminishes in cells with age.

The diminished NAD+ levels are directly linked to age-related disorders, metabolic issues and cardiovascular dysfunction. An enzyme called CD38 plays a key role in the maintenance of NAD+ levels, as it’s the main enzyme responsible for the degradation of NAD+. Higher CD38 levels correlate with lowered NAD+ levels in the body. Senescent cell accumulation is also associated with an increase in CD38 and contributes to age-associated NAD+ decline.

STUDIES HAVE SHOWN

Researchers discovered that lowering CD38 levels through the use of a CD38 inhibitor, or by increasing NAD+ levels through supplementation with NMN, they were able to block the development of cardiovascular diseases in mice.(3) By lowering CD38 levels, NAD+ levels increased and this led to lowering of blood pressure and lowering of blood vessel senescent cells. CD38 is a major consumer of NAD+ in the cells. Mice lacking in CD38 or treated with the CD38 inhibitor apigenin had about 50% higher NAD+ levels. (4) In addition, apigenin has numerous small studies showing other possible benefits, including: improvements in depression and anxiety, memory and learning, weight loss and improved metabolic health.

  • Benefits: Immune Support, Metabolic Health, Neurological Health

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BERBERINE

LIPO Berberine - Alive By Science Berberine’s unique ability to lower blood sugar, stimulate weight loss, lower cholesterol levels and improve heart health, have made it an increasingly popular supplement.

WHY IT'S IMPORTANT

Blood sugar and insulin problems, weight gain and other metabolic issues and diseases like diabetes are common in the aging population. These issues contribute to a range of health problems. Chronic high blood sugar levels can cause damage to the body’s tissues and organs, leading to numerous health problems and contributing to a shortened lifespan. Lifestyle and dietary interventions play an important role in maintaining metabolic health. Senescent cell levels increase with inflammation, metabolic issues, obesity, diabetes and insulin resistance.

STUDIES HAVE SHOWN

Numerous studies show that berberine significantly reduces blood sugar levels in people with type 2 diabetes.(13) It is often recommended as a natural alternative to the prescription drug Metformin. Berberine works by decreasing insulin resistance, helping the body to break down sugars inside cells, decreasing sugar production in the liver, slowing down the breakdown of carbohydrates in the gut, while increasing beneficial bacteria. In one study of diabetic patients, those taking berberine had a 20% lower fasting blood sugar level and went from diabetic to normal levels. It’s also been shown to improve cholesterol levels and triglycerides.(14) It’s currently being studied as a potential senolytic. In a study, activation of AMPK with berberine significantly prevented the development of senescence.(15)

  • Benefits: Metabolic Health, Cardiovascular Support

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CaAKG

Lipo CaAKG - Alive By Science Calcium Alpha-Ketoglutarate (CaAKG) shows great promise in numerous studies and plays an important role in the aging process.

WHY IT'S IMPORTANT

Aging is associated with a dysregulated epigenome. Epigenetics is the study of how cells control gene activity without changing the DNA. Epigenetic changes play a part in whether genes are turned on or off. When dysregulated, this leads to epigenetic errors and conditions such as cancers, metabolic disorders and degenerative diseases. Epigenetic dysregulation is closely correlated with aging.

STUDIES HAVE SHOWN

CaAKG is a regulator of epigenetic processes and provides energy to the mitochondria. It works in numerous pathways in the body and helps build muscle and heal wounds. It plays a role in amino acid metabolism and carbohydrate metabolism, helping cells maintain metabolic flexibility. A number of studies have shown that CaAKG influences aging and in numerous studies it has extended lifespan in organisms. In one study, dietary supplementation increased both median and maximum lifespan in flies.(11) In a recent study, researchers found that mice given CaAKG experienced a 12% increase in lifespan, and a 46% reduction in frailty, and 41% increase in healthspan.(12)

CaAKG is often given to athletes and bodybuilders in order to boost physical endurance and energy by providing fuel to the mitochondria. CaAKG has also been studied for its ability to enhance autophagy. Autophagy is the body’s way of cleaning out damaged cells, and the body’s autophagic activity declines with age, contributing to the development of disease.

  • Benefits: Immune Support, Metabolic Health, Epigenetic Support, Skin Health

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FISETIN

Liposomal Fisetin Fisetin is a potent compound that may help slow degenerative aging processes by selectively destroying and clearing out senescent cells.

WHY IT'S IMPORTANT

Aging is associated with the buildup of senescent cells. Senescent cells are dysfunctional cells that are difficult to clear out of the body. When they aren’t cleared out, they cause damage to surrounding healthy cells by releasing proinflammatory substances. Senescent cell accumulation contributes to age-related diseases, such as: glaucoma, liver cirrhosis, Type 2 diabetes, cancer, sarcopenia, osteoarthritis and cardiovascular disease. The accumulation of senescent cells also contributes to a decline in immune function.

STUDIES HAVE SHOWN

Fisetin’s ability to clear out senescent cells has been shown to calm inflammation, improve physical function and increase lifespan in animals.(1,2) It’s benefits in studies are vast: from improved metabolic function and blood sugar levels, pain reduction, lowered cholesterol levels and blood pressure, while improving bone density. Studies have also demonstrated its ability to prevent the breakdown of collagen from UV/sun exposure.

  • Benefits: Immune Support, Metabolic Health, Skin Health, Joint & Mobility Support

More info on Fisetin LIPO Gel

GLUTATHIONE

Liposomal Glutathione - Alive By Science Glutathione is the body's master antioxidant and optimal levels are vital to healthy aging and disease prevention.

WHY IT'S IMPORTANT

Glutathione deficiency is recognized as a risk factor in coronary artery disease, asthma, neurodegenerative disorders, cognitive-behavioral problems, and various types of cancer. As you age, your body requires higher levels of glutathione for optimal health.

STUDIES  HAVE SHOWN

Benefits in mitochondrial function, improvement, lessened inflammation, improved endothelial functioning, improved exercise capacity and lowered body-fat and waist-circumference.

  • Benefits: Immune Support, Metabolic Health, Fitness Capacity

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HYALURONIC ACID

Lipsomal Hyaluronic Acid Supplements Hyaluronic acid’s benefits are multifaceted & supplementation has shown great promise in clinical studies, with improvements in tissue hydration & skin appearance, joint health and improvements in mobility.

WHY IT'S IMPORTANT

The physical impacts of aging can be difficult and painful to deal with. Aging is associated with joint & mobility issues, stiffness, pain and numerous osteoarthritic conditions. Hyaluronic acid is a naturally occurring protein and it’s found in every tissue in the human body. Approximately half of the hyaluronic acid in your body is found in your skin and synovial fluid, which is contained in the knees and other joints. It plays an important role in joint lubrication and mobility. Declining levels in the body are associated with joint pain, inflammation and disability. Hyaluronic acid levels also play an important role in your skin’s appearance. Skin aging correlates with the loss of skin moisture and an increase in wrinkles and skin laxity. The key molecule involved in skin moisture and it’s youthful appearance is hyaluronic acid.

STUDIES  HAVE SHOWN

Lower levels of hyaluronic acid in the knee joint was shown to be directly correlated to pain and the degradation of synovial fluid.(7) Synovial fluid's job is to provide cushion and lubrication for joints. Synovial fluid contains high levels of hyaluronic acid and that aids in maintaining the integrity of the joint, lessening inflammation and preserving its function. A 2015 study reported that a three-month course of hyaluronic acid supplementation provided relief to overweight adults dealing with osteoarthritis. They experienced a steep reduction in inflammatory proteins called cytokines, and an increase in the concentration of hyaluronic acid in joint fluids, a reduction in pain and improvement in joint function.(8) Two animal studies have shown that hyaluronic acid supplements can help to slow down the rate of bone loss in rats with osteopenia.(9)
Skin improvements were also noted in numerous studies. A 2017 study showed a reduction in wrinkle depth and volume, improvement in skin’s luster, appearance and suppleness, after 12 weeks of treatment with hyaluronic acid supplements.(10)

  • Benefits: Joint & Mobility Support, Bone Health, Skin Health

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QUERCETIN

Liposomal Quercetin Supplement A powerful anti-inflammatory, known for its potent antioxidant, antiviral and antihistamine properties

WHY IT'S IMPORTANT

Oxidative stress is a process that occurs due to an imbalance between antioxidant activity and free radical activity in the body. When free radicals accumulate, they are kept in check by antioxidants. Substances that generate free radicals include: food, medicine, pollution and other chemicals. If the antioxidants can't maintain a balance and the free radical accumulation worsens, this leads to damage to your DNA, fatty tissues and proteins in your body. The damage contributes to an array of age-related issues: from diabetes, blood vessel hardening, hypertension, neurological conditions and heart disease.

STUDIES  HAVE SHOWN

Research on quercetin suggests it can neutralize free radicals while reducing the body’s oxidative damage. It’s also been studied for an array of other potential health benefits, from possible blood pressure reduction, blood sugar regulation, improvements in cholesterol levels, protection against degenerative neurological conditions often associated with aging, lessened pain and stiffness related to joint function, and allergy-symptom relief.

It’s also been shown to support cellular energy production through mitochondrial biogenesis, or the production of new mitochondria. Researchers have discovered it’s a powerful CD38 inhibitor.(5) It’s also becoming increasingly popular for allergy-sufferers. Quercetin inhibits the production and release of histamine and other allergic and inflammatory substances by stabilizing cell membranes of mast cells and lowering inflammation with the allergen-induced immune response.(6)

  • Benefits: Immune Support, Metabolic Health, Neurological Health, Joint & Mobility Support, Allergy Relief, Cardiovascular Support

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RESVERATROL

Liposomal Resveratrol A popular sirtuin-activator that can boost cellular energy and improve mitochondrial function, while offering cardiovascular & immune system support.

WHY IT'S IMPORTANT

Sirtuins play a key role in regulating metabolic health, circadian rhythm, detoxification and cellular aging. Sirtuin-activating compounds are being studied for the treatment of a variety of inflammatory and metabolic disorders. Resveratrol is a sirtuin-activator which plays a key role in regulating metabolic health, circadian rhythm, detoxification and cellular aging. Sirtuin-activating compounds are being studied for the treatment of a variety of inflammatory and metabolic disorders.

Inflammation is one of the driving forces of aging and age-related diseases. Although it has a notable impact on the aging population, it also impacts younger people as well. Common symptoms of inflammation include: fatigue, depression, gastrointestinal issues and infections. Unhealthy dietary choices, stress, smoking and other pollutants can contribute to inflammation. Over time, chronic inflammation can lead to damaged DNA, mitochondrial issues and disease development.

STUDIES  HAVE SHOWN

Resveratrol’s benefits are vast and studies have shown evidence of its positive and protective impact on heart disease, metabolic syndrome and neural degeneration in animal studies. One key feature of resveratrol is its ability to activate sirtuins. It also improves cellular energy and mitochondrial function, while offering cardiovascular & immune system support. In studies, resveratrol has increased the lifespan of fish, fruit flies, worms, yeast and mice which were fed a high-calorie diet. Studies on resveratrol have reported a reduction in age-associated symptoms, plus the prevention of early mortality in obese animals(21,22) and in another study it slowed down and prevented cognitive deteoration in mice.(23)

  • Benefits: Immune Support, Metabolic Health, Neurological Health, Cardiovascular Support

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RESVERATROL/CURCUMIN

Resveratrol and curcumin offer protection against age-related conditions driven by inflammation, while activating sirtuins and by providing antioxidant support.

WHY IT'S IMPORTANT

Sirtuins play a key role in regulating metabolic health, circadian rhythm, detoxification and cellular aging. Sirtuin-activating compounds are being studied for the treatment of a variety of inflammatory and metabolic disorders.

Inflammation is one of the driving forces of aging and age-related diseases. Although it has a notable impact on the aging population, it also impacts younger people as well. Common symptoms of inflammation include: fatigue, depression, gastrointestinal issues and infections. Unhealthy dietary choices, stress, smoking and other pollutants can contribute to inflammation. Over time, chronic inflammation can lead to damaged DNA, mitochondrial issues and disease development.

STUDIES HAVE SHOWN

RESVERATROL

Resveratrol’s benefits are vast and studies have shown evidence of its positive and protective impact on heart disease, metabolic syndrome and neural degeneration in animal studies. One key feature of resveratrol is its ability to activate sirtuins. It also improves cellular energy and mitochondrial function, while offering cardiovascular & immune system support. In studies, resveratrol has increased the lifespan of fish, fruit flies, worms, yeast and mice which were fed a high-calorie diet. Studies on resveratrol have reported a reduction in age-associated symptoms, plus the prevention of early mortality in obese animals(21,22) and in another study it slowed down and prevented cognitive deterioration in mice.(23)

CURCUMIN

Curcumin is the active compound in turmeric, and has been studied extensively for multiple conditions. It has been shown to benefit inflammatory conditions (24), metabolic syndrome, pain (25), and to help in the management of inflammatory and degenerative eye conditions (26,27). Most of the benefits of curcumin supplementation are derived from its antioxidant and anti-inflammatory effects. In one randomized double-blind placebo-controlled human, supplementation with curcumin improved working memory, performance and sustained attention. Biomarkers also showed a significantly reduced total and LDL cholesterol.(28)

It’s also been studied for pain and inflammation-related symptoms from arthritis. One study showed that curcumin, when taken for 8-12 weeks at 1000mg/day, offered pain-relief and symptom-relief that was similar to that of taking ibuprofen and diclofenac sodium.(29)

  • Benefits: Immune Support, Metabolic Health, Neurological Health, Cardiovascular Support, Pain Relief

More info on Resveratrol w/Curcumin LIPO Gel

D3/K2

Liposomal D3/K2 Proper functioning of the immune system depends on sufficient levels of vitamin D. Both Vitamin D and Vitamin K2 play central roles in calcium metabolism, which is vital for maintaining healthy bones, for regulating heart rhythm, blood pressure and other vital cellular functions.

WHY IT'S IMPORTANT

As you age, your skin’s ability to manufacture vitamin D from the sun diminishes and this can lead to a vitamin D deficiency, which is a common problem. People who live in colder climates and those who work indoors are more likely to suffer from it. In addition, people with darker skin are also less able to produce vitamin D from sunlight and are at a higher risk for deficiency.(30)

Symptoms of a vitamin D deficiency in adults include: tiredness, aches and pains, bone or muscle pain, weakness, stress fractures, illness and depression.

STUDIES HAVE SHOWN

Correcting a deficiency is important for multiple reasons. The vitamin is so critical to immune function that low levels are associated with an increased susceptibility to infection, disease, and immune-related disorders.(31) Research shows that vitamin D deficiency is also linked to decreased lung function, which may impact your body’s ability to fight respiratory infections.(32) 

It also plays an important role in regulating mood and warding off depression. In one study, scientists found that vitamin D supplementation improved symptoms for those suffering from depression.(33)

Vitamin D has other roles in the body, including reduction of inflammation as well as modulation of such processes as cell growth, neuromuscular and immune function, and glucose metabolism.(34)

  • Benefits: Immune Support, Metabolic Health, Neurological Health, Cardiovascular Support

More info on Liposomal D3 & K2

REFERENCES
  1. https://journals.sagepub.com/doi/full/10.1177/2040622320964125
  2. https://www.ncbi.nlm.nih.gov/pubmed/29988130 
  3. https://doi.org/10.1038/s41392-021-00625-0 
  4. https://www.cell.com/cell-metabolism/comments/S1550-4131(18)30122-0#bib71 
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609577/ 
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273625/ 
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621876/
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603175/
  9. https://pubmed.ncbi.nlm.nih.gov/23256527/
  10. https://www.ncbi.nlm.nih.gov/pubmed/15573687
  11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629006/
  12. https://pubmed.ncbi.nlm.nih.gov/32877690/
  13. https://www.ncbi.nlm.nih.gov/pubmed/25607236 
  14. https://www.ncbi.nlm.nih.gov/pubmed/18397984
  15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854918/ 
  16. https://journals.sagepub.com/doi/full/10.1177/2040622320964125
  17. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649683/#B13 
  18. https://www.frontiersin.org/articles/10.3389/fphar.2020.00421/full#B36 
  19. https://pubmed.ncbi.nlm.nih.gov/33287432/ 
  20. https://pubmed.ncbi.nlm.nih.gov/33183192/ 
  21. https://www.ncbi.nlm.nih.gov/pubmed/18599363/ 
  22. https://www.ncbi.nlm.nih.gov/pubmed/18523577/ 
  23. https://www.ncbi.nlm.nih.gov/pubmed/19571741/ 
  24. https://www.ncbi.nlm.nih.gov/pubmed/18662800/ 
  25. https://www.ncbi.nlm.nih.gov/pubmed/24672232/ 
  26. https://www.ncbi.nlm.nih.gov/pubmed/23723686/
  27. https://www.ncbi.nlm.nih.gov/pubmed/21060672/ 
  28. https://www.ncbi.nlm.nih.gov/pubmed/25277322/ 
  29. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003001/ 
  30. https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/#en1 
  31. https://pubmed.ncbi.nlm.nih.gov/21527855/ 
  32. https://pubmed.ncbi.nlm.nih.gov/21297070/
  33. http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2796.2008.02008.x/abstract
  34. https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/#en1