New research shows NMN may protect and restore skin from UV damage – ALIVE BY SCIENCE – Bioavailable NAD+ Boosters

New research shows NMN may protect and restore skin from UV damage

A woman sunbathing
New research indicates UV radiation can deplete NAD+ reserves, damage DNA, and accelerate aging

In two new studies, NMN was shown to play a vital role in protecting and reducing damage to skin from the harmful effects of UV radiation. Repeated exposure to UV radiation has been shown to prematurely age the skin, using pathways that include inflammation and the response to oxidative stress.

UV radiation can deplete NAD+ reserves, damage DNA, and accelerate aging

Restoring NAD + by NAMPT is essential for the SIRT1/p53-mediated survival of UVA- and UVB-irradiated epidermal keratinocytes

In this study published in June 2021 it was found that UV rays cause DNA damage, which requires vast stores of NAD+ in the repair process, leading to what is called “UV-induced NAD+ depletion”.

This becomes even more problematic as we age and begin to produce less and less NAD+. As levels of NAD+ drop and DNA damage goes unrepaired, DNA damage accumulates, cells become dysfunctional or senescent, stop proliferating, and aging is accelerated.

Supplementing with NMN restored NAD+ levels and the cells ability to recover from UV damage

Researchers affirmed that supplementing UV-damaged skin cells with NMN restored energy production and the proliferation of cells and that levels of NAD+ remained adequate, even during UV damage.

“identifies novel candidate molecules, NMN and NR, as potential therapeutic and preventive agents for age-associated skin disorders and functional decline” (2)

“Therefore, NAD+ homeostasis is likely essential for the protection of keratinocytes from UV stress in mild doses.” (2)

“the availability of intracellular NAD+ decreases with age or exposure to UVB irradiation, thereby promoting aging of the skin or body.” (2)

NMN and NR can maintain cellular NAD+ levels to prevent skin damage from sun exposure

In the study, although they found that UV radiation substantially depleted NAD+ levels, NAD+ precursor supplementation increased NAD+ levels in UV-damaged skin cells to promote cell energy production and proliferation, providing a potential skin aging treatment.

“NMN and NR could maintain cellular NAD+ levels as NAD+-boosting agents and prevent the keratinocytes from UVA/B-induced proliferation defects.” (2)

“Evidence indicates that the availability of intracellular NAD+ decreases with age or exposure to UVB irradiation, thereby promoting aging of the skin or body.” (1)

The decline of NAD+ levels as we age is linked to many disorders, including the so-called “diseases of old age” such as metabolic disorders, cancer, heart and neurodegenerative diseases, among others.

The protective and restorative effects of NMN on skin demonstrated in these studies are in keeping with previous NMN studies, including recent human trials showing the numerous health and longevity benefits of NMN and other NAD+ boosters.

NMN eliminated free radicals that play crucial role in UV radiation-induced aging

Nicotinamide Mononucleotide Combined With Lactobacillus fermentum TKSN041 Reduces the Photoaging Damage in Murine Skin by Activating AMPK Signaling Pathway

This study published in March 2021 showed that free radicals in skin cells play a crucial role in UV radiation-induced aging.  In that study, mice that had skin damaged by UV radiation and drank water containing NMN showed greater free radical scavenging.  Since free radicals in skin cells play such a crucial role in UV radiation-induced aging, their elimination by NMN, as well as a bacterium called lactobacillus fermentum that was also tested, showed how effectively NMN protected skin from harmful UV radiation.

“These results show that NMN combined with LAB resists the oxidative stress of the skin caused by UVB irradiation” (1)

Researchers also wanted to find out whether NMN could have the same protective ability on mice that were given an intense 2-week period of UVB radiation exposure. When looking at the exposed skin under a microscope, researchers discovered that the NMN treatment significantly preserved the dermal layer of the skin, which is a blood vessel-containing layer just under the surface.

NMN shows antioxidant and anti-inflammatory properties

With it’s ability to boost NAD+, NMN was also shown to have antioxidant and anti-inflammatory properties. As evidence of this, cells that were indicative of inflammation, called mast cells, were reduced by half.  The results of mice treated with NMN were similar to that of mice with no UVB radiation exposure whatsoever.

NMN may promote the health of skin cells as we age

Both studies support the conclusion that boosting NAD+ levels with supplements like NMN can promote the health of skin cells as we age. These studies would also lend support to the idea that topical use of NMN and NAD+ can restore skin NAD+ levels, repair the skin, and serve as protection from UV radiation.

“Our results suggest that these intermediates can effectively prevent photodamage and age-related” (2)

 

Skin’s Appearance & Evidence of Damage

Evidence of damage may appear in numerous ways. Chronological aging is characterized by thinning of the skin, which appears as dryness and wrinkles. UV-damaged skin has a thicker, leathery-like appearance with deeper wrinkles and pigmentation issues. (Source)

Cellular NAD+ pools are lower in aged skin. Mitochondria are one of the primary targets of damage from chronological and UV-induced skin aging. (Source, Source)

“Several studies have directly or indirectly linked mitochondrial dysfunction to both chronological and photo-aging of the skin.” Mitochondria in Skin Health, Aging, and Disease, Cell Death & Disease

Mitochondrial Dysfunction & Depletion of NAD+

An increase in oxidative stress contributes to the depletion of NAD+ and ATP (a molecule that carries energy within a cell). The damage contributes to mitochondrial dysfunction in both the short-term & long-term, creating a   cumulative impact.

NAD+ Regulates Mitochondrial Maintenance

Mitochondrial maintenance through mitophagy (selectively eliminating the defective mitochondria) and mitochondrial biogenesis (synthesis and production of new mitochondria) is vital to cellular homeostasis and health. (Source)

NAD+ regulates mitochrondrial maintenance. In this study, when levels of NAD+ in old mice were raised, their mitochondrial function was restored to that of young mice. (Source)

“NAD+ and its primary precursor nicotinamide have been known for some time to impact skin homeostasis based on linkages to dietary requirements, treatment of various inflammatory conditions, photoaging…” – The evolving role of the NAD+/nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging

Increasing NAD+ Levels in the Skin

Delivery of NAD+ through transdermal liposomal serums and lotions, is an optimal way to safely raise levels of NAD+ in the skin. In dermal fibroblasts (cells within the dermis), nicotinamide protects against oxidative stress, glycolisis, oxidative phosphorylation and increases mitochondrial efficiency. (Source)

Low NAD+ levels are common in aging skin, and directly contribute to impairement in mitochondrial function and ATP production. Numerous factors contribute to the impaired hormeostatic state of the skin and numerous methods can be used to treat it.

Targeted nutrient therapy with NAD+ and other active ingredients, delivered through transdermal liposomal skincare formulations, is one way to address numerous skin-aging issues. Raising NAD+ levels can create a positive cascading effect on numerous processes.

“Bioactive compounds targeting the mitochondria have proved effective against age-related as well as UV-induced skin damage, in addition to different skin diseases with mitochondrial involvement.” The evolving role of the NAD+/nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging

Renue delivers nmn directly to the skin

While these studies, and others, show orally delivered NMN has great potential to reach skin cells to restore NAD+ and maintain healthy skin as we age, delivering NMN directly to the skin is much more efficient.

Our Renue skin care products use Liposomes to safely carry NMN, NAD+, and other highly effective ingredients through the surface layers of the skin to protect and restore damage as we age. 

The formulation allows for these potent ingredients to reach the target site before releasing them to offer a targeted skin treatment.

Learn More.

 

References:

1 – Nicotinamide Mononucleotide Combined With Lactobacillus fermentum TKSN041 Reduces the Photoaging Damage in Murine Skin by Activating AMPK Signaling Pathway

2 – Restoring NAD + by NAMPT is essential for the SIRT1/p53-mediated survival of UVA- and UVB-irradiated epidermal keratinocytes