However, NR is not stable in circulation and degrades in plasma such that NR disappears from the bloodstream and is almost undetectable 45 minutes after injection at 50 mg/kg. (4)
Therefore, a more effective delivery method is necessary to overcome the numerous instability and absorption issues of NR (7).
Liposomes are a revolutionary way of encapsulating active ingredients to protect and deliver them directly to the cells of our tissues, which are reached via the bloodstream.
They are specialized delivery vehicles serving multiple roles in enhancing the capabilities of active ingredients.
Liposomes stabilize therapeutic compounds—overcoming obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites.
LIPO NR encapsulates nanosized NR particles in Liposomes, which are then freeze-dried to remove the aquaeus phase.
Our unique powder-based encapsulation ensures maximum bio-availability and stability, protecting the bio-active ingredients against degradation.
This encapsulation technology is clinically proven through safety, absorption and blood glucose studies to maximize nutrient bioavailability. (8)
A peak particle size of less than 50 nm (nanometers) ensures the maximum bioavailability and stability.
The advanced liposomes retain the core structure of the liposomal bilayer in its powder form, which stabilizes NR and ensures maximum bioefficiency, potency and absorption.
We use natural non-hydrogenated sunflower phosphatidylcholine in our manufacturing process, derived from non-GMO certified sunflower oil from Europe. It undergoes a multi-step, purification and filtration process during liposome manufacturing to ensure the utmost purity.