Best Use Practice:
The pump mechanism is loaded. It may take 10-20 pumps to prime before first use.
Target the tip of the pump under the tongue. Press down to administer LSG™. Put the cap back on the pump when finished.
If swallowed, liposomes do protect the active ingredients from digestion in the stomach, but it is preferable to let the gel absorb under the tongue or elsewhere in the oral cavity as much as possible.
LSG™ NMN is nanoliposome-encapsulated Nicotinamide Mononucleotide, offering advanced absorption in sustained release sublingual hydrogel technology.
Our liposomes encapsulate NMN into nanometer sized vesicles – between 20-40 nm – to protect it from denaturation.
Our LSG delivery system protects the full functionality of NMN.
NMN engulfed in liposomes protects it from degradation, providing its unmetabolized form directly to cells and tissues.
LSG™ (Liposomal Sublingual Gel) – An Innovation in Liposome Science
Liposomal Sublingual Gel (LSG™) is a novel nanoliposomal nutrient delivery system with Control Release Kinetics™ offering enhanced performance.
LSG™ patent pending nanotechnology utilizes pharmaceutical grade organic, non-GMO phospholipids designed to deliver unmetabolized nutrients to cells and tissues.
LSG™ nanoparticles are 20-40 nanometers – smaller than wavelengths of visible light to maximize biological efficiency and precision performance.
This advanced sublingual delivery system features Control Release Kinetics™, using sustained release liposomes to protect nutrients before release into systemic circulation with improved efficacy.
The improved potency and function of nutrient delivery requires fewer doses.
Our nanoparticulate Hydrogel technology is formulated to improve active compound permeability across the epithelium, provide optimal solubilization and maximize systemic release kinetics.
LSG™ nanoparticulate composition is suitable for both hydrophilic and hydrophobic micro- and macromolecules and offers enhanced transcellular and paracellular delivery.
LSG™ technology was specifically designed for the advanced absorption of compounds into the mucosal matrix and works in concert with the pH and flow of saliva to control the rate of disintegration into the sublingual region effectively.
This advanced permeability across the epithelium is designed to promote higher systemic absorption and uptake of compounds.
LSG™ technology is manufactured in a heat-free, pressure-free and solvent-free manufacturing process to preserve potency and stability.
We use 100% natural liposomes made from organic sunflower lecithin that contain essential phospholipids with a high percentage of phosphatidylcholine.
LSG™ nanoliposomes provide superior transport of active nutrients while helping to satisfy the body’s need for choline.
With a 0.1-0.7 mm thick mucus layer, the oral cavity is an effective route of administration for mucoadhesive dosages.
The highly permeable sublingual entry site can be utilized for both rapid onset (e.g. powder supplements and sublingual tablets) and longer dosage durations when administered in the form of a bioadhesive.
Our LSG™ technology provides controlled-release performance with liposomes suspended in a natural bioadhesive gel. The loaded hydrogel increases contact time to improve performance over liquid products where production of saliva induces swallowing rather than sublingual absorption.
The LSG™ nanoparticulate system is designed to improve the accumulation, uptake and absorption across the biological barrier of the skin, in both sublingual and transdermal applications.
Our mucoadhesive gel is designed to adhere to biological tissues, prolong residence time and maintain an optimal release rate.
Advanced Hydrogel Suspension Technology
Liposomal drug delivery systems have excellent biocompatibility, low toxicity, and lack of immune system activation. Creating homogeneous liposome particle sizes that are stable and hold their encapsulated payload is challenging.
We partnered with chemists who have a proven track record in liposome science achievements within the pharmaceutical sector to design structurally uniform nanoliposomes using organic phospholipids.
Together, we were able to achieve a novel bioadhesive nanoliposome delivery method offering improved performance, functionality and efficacy of dietary supplements.
The mucoadhesive gel in our LSG products is designed to avoid rapid clearance of nutrient nanoparticles and maintain a long-term concentration gradient at the mucosal surface to ensure the unidirectional diffusion, and provides unsurpassed bioavailability with higher systemic delivery of nutrients to systemic circulation.
What is a liposome?Liposomes are vesicles comprised of phospholipid molecules – the same molecules that comprise cell membranes. The phospholipid molecule consists of a hydrophilic phosphate head and two hydrophobic fatty acid tails. These features enable liposomes to be the carriers of hydrophobic and hydrophilic compounds. Due to low absorption and bioavailability rates of traditional oral dietary capsules, the encapsulation of hydrophilic and hydrophobic nutrients within liposomes allows the active ingredient to bypass the destructive elements of the gastric system. To release the protected molecules to a site of action, the lipid bilayer fuses with other bilayers such as the cell membrane, delivering the liposome contents directly into the cells and tissues intact.
What is phosphatidylcholine?One of the most important and prominent phospholipids in cell membranes is called phosphatidylcholine (PC) [pronounced FOSS-fah-tide-al-KOH-lean]. At birth up to 90% of cellular membranes are made up of PC. As you age, the percentage of PC in your cellular membranes can decrease to about 10%. This fact leads many to recommend consistent supplementation with this essential phospholipid.
What does phosphatidylcholine do?Phosphatidylcholine is required for many vital functions in the cardiovascular, reproductive, immune, and nervous systems. PC and its components are needed for the synthesis of important messenger molecules called prostaglandins which, among other functions, regulate the contraction and relaxation of muscles. Choline is required for the synthesis of intracellular messenger molecules including the neurotransmitters that allow nerve cells to communicate with muscles and each other, and are essential for proper heart and brain function.
Increases BioavailabilityLiposomes release drug molecules by membrane fusion. They delay the clearance and increase the intravascular circulation time of encapsulated drugs, decreasing digestion of liposomes by macrophages in the reticulo-endothelial system (RES), and enhancing the retention of drugs. The drug encapsulated in the liposome is protected from metabolism and the drug molecule becomes active only after release from liposome (r). These encapsulating phospholipids bond with cell membranes to facilitate intracellular delivery. They are successful in this because they are able to bypass the digestive processes that normally degrade foreign substances.
Crosses the Blood Brain BarrierHave you ever heard of the blood-brain barrier? This is a filtering mechanism in our circulation system that allows blood to be carried to the brain but blocks numerous other substances from passing through. Nanoliposomes have demonstrated the ability to cross this barrier, giving the liposomes the ability to deposit the supplement directly into the cells and enhance circulation of nutrients by your lymphatic system.
Research on Lipsomes for increased bioavailabilityLiposomes protect products from digestion in the GI tract, but that is only the first step. The improved bioavailability varies greatly, depending on the molecule itself and the quality of the liposome. Water solubility. Molecules with very poor water solubility usually have the worst bioavailability and can benefit the most from liposomal delivery. Fisetin is one example shown below up to 27x more bioavailable. Liposome Stability. Liposomes need modification to increase stability so they do not break apart and release their payload when exposed to the GI tract and bloodstream. Recent advances in Liposomal technology enables skilled manufacturers to adjust the stability so the payload is protected for several hours. Different manufacturing techniques result in significant variation in stability and bioavailability. Liposome size. As noted above, size of the liposome is crucial. Larger Lipsomes are quickly filtered out by the liver and other parts of the RES. Smaller liposomes (below 50 nanometers) can circulate much longer. The study on B-12 below shows the larger size liposome formula increased bioavailability of 3xvs 5x for the smaller sized liposomal formula.
Liposomal Fisetin 1.6 to 27x more bioavailableThis study in mice found a 2.7-fold increase (in Cmax) with Liposomal Fisetin, with a dose 10 times lower than that of the free fisetin when given by IP. With IV, the Cmax of liposomal fisetin was 10, vs 6 for free fisetin.
Liposomal Vitamin B-12 formulas 3-5x more bioavailable than tablet.
- (i)Nanocelle 1000ug -28% - A nano liposomal formulation of B12sublingual spray with an average particle size of about 20 nm