Renue™ – Topical Lotion with Liposomal NAD+ (120 mL) – ALIVE BY SCIENCE – All about NAD+

Renue™ – Topical Lotion with Liposomal NAD+ (120 mL)

$74.95

Renue™ delivers the transformative power of NAD+ along with Apocynin and Resveratrol across the layers of the skin using breakthrough nanoliposome technology. Renue™ works at the cellular level to deliver time-released actives that restore NAD+ to improve skin’s texture, firmness and dermal matrix.

5 ml (5 pumps) provides 250 Mg  NAD+ Complex.  Bottle contains 120 ml.

In stock

RENUE™ Topical Body Lotion

Renue™ Topical Body Lotion protects and renews cells from within using a proprietary Liposomal NAD+ Complex and science-backed nutrients that provide nourishment on the cellular level.

Expertly formulated with liposomal NAD+ Complex (NAD+, NMN and NR), this potent delivery system offers a deeper penetration of key ingredients into the skin’s surface to combat the most visible signs of aging and promote vibrant, youthful looking skin.

Use day and night with Renue™  Face or Body Serums to restore cellular vitality to all layers of skin. Suitable for all skin types.

 

RENUE™ - 2 Step Skin Rejuvenation Protocol 

 

 

 

 

Ingredients

Active Ingredients

  • NAD+ Complex: Nicotinamide Adenine Dinucleotide (NAD+) · Nicotinamide Mononucleotide (NMN), Nicotinamide Riboside (NR)
  • Resveratrol
  • Apocynin

Helianthus Annuus (from Sunflower Lecithin) · Aloe Barbadensis (Aloe Vera) · MCT Oil (Coconut Derived) · Shea Butter ·  Tocopherols (Vitamin E) · Rosmarinus officinalis (Rosemary) · Citric acid

Emollients & Stabilizers

Aqua (Water) · Cetearyl Alcohol · Glyceryl Stearate · Phenoxyethanol · Potassium Sorbate · Sodium Benzoate

 

Resveratrol

“The Longevity Molecule"

Resveratrol is a stilbenoid polyphenol synthesized by plants in response to stressful stimuli and is protective in aging. 9, 10, 6

Its broad-spectrum properties (antimicrobial, anti-inflammatory, antioxidant and anti-aging) make it a potent bioactive for dermatological application by limiting the effects of cellular aging. 11

Its antioxidant activity (95%) is higher than vitamin E (65%) and C (37%) and has been shown to be active in neutralizing and inhibiting the formation of reactive oxygen species. 6, 12

Apocynin

The Skin Cell Tonic”

Apocynin, a natural vanilloid compound, has emerged as a bioactive phytochemical with potent anti-inflammatory properties for the skin. 13

A new paper published in Nature, found that declining levels of a collagen protein called COL17A1 (Collagen 17), cause our skin to develop wrinkles, sag and lose elasticity. 4

Apocynin was able to restore levels of Collagen 17 and repair damaged skin, leading scientists to believe it’s possible to reverse our skin’s timeline at the cellular level. 14

NAD+

"The Youth Molecule"

May Improve Rosacea

According to research Topical NAD+ has been shown to improve metabolism of skin cells. Its profound antioxidant properties can lessen inflammation that is associated with the damaging effects of free radicals.

May Improve Psoriasis

According to this study, it’s as effective as the leading pharmaceutical at treating psoriasis, and without side effects. NAD+ mitigates cellular damage and lessens inflammation, which leads to a visible improvement in the skin.

More about Resveratrol

More about Apocynin

More about NAD+

Research

NAD+ reduces oxidative cell damage

Oxidative stress and chronological aging can cause NAD+ breakdown in the skin. The NAD+ metabolic pathway has been implicated as a therapeutic target to promote cellular health. Recent studies have shown that enhancing NAD+ levels can reduce global oxidative cell damage, replenish total NAD+ stores and restore optimal skin cell function.

Link to research >>

Resveratrol increased skin hydration by 201%

Resveratrol topical application increases human epidermal hydration, skin elasticity and skin thickness, reduces skin wrinkles, and augments collagen and vascularization.In a recent study, resveratrol emulsions significantly influenced the hydration level of the epidermis, showing an increase in hydration by 201% after 4 weeks.

Link to research >>

Oleic Acid enhances skin barrier permeability

Free fatty acids (FFAs), specifically monounsaturated FFAs such as oleic acid, may disrupt skin barrier and act as permeability enhancers for other compounds present in plant oils. David Sinclair recently stated that he is using Oleic Acid, which stimulates the longevity-linked protein Sirt1 and maintains skin health.

Link to research >>

NAD+ research for skin rejuvenation

Skin aging is driven by both external and internal factors such as sun exposure (UV), stress, environmental toxins and the natural mechanisms of aging occurring in all cells and tissues. Tissues with a high cellular turnover, such as the skin, require higher doses of NAD+ to counteract daily genomic threats, activate sirtuin proteins, and to rejuvenate skin.

Link to research >>

Apocynin stimulates growth of collagen in deepest layer of skin

Apocynin is the only known substance able to stimulate growth of the deepest layers of collagen (COL17A1) and repair damaged skin, leading scientists to say it may be possible to reverse our skin’s timeline at the cellular level. Apocynin is well known as a NADPH oxidase inhibitor and has powerful anti-inflammatory effects on the skin.

Link to research >>

Liposomes an ideal drug-carrier system


Liposomes seem to be an almost ideal drug-carrier system.Micro-vesicle technology can act as a platform for the transdermal delivery of various micronutrients such as NAD+ through the skin using fluidizing liposomes incorporated within standard cosmetic bases.Liposomes circulate the blood the longest, leading to longer half-life of the substance.

Link to research >>

Videos

"I have a skincare product that I am really loving right now and it's a mix between a skincare product and a supplement." - Claudia Glows

 

"This will really help maintain your levels of collagen." - Madison Hildreth

"It feels like I'm putting liquid gold on my arm." - Madison Hildreth

 

Testimonials

The following are uncompensated testimonials from some of our happy customers.

 

Renue Trial Participant's Results - Before and after Renue Serum

I LOVE these products!

"I've definitely noticed less redness and smoother skin around my eyes and forehead. I LOVE these products! They are the only ones I'd ever use going forward because I see actual results. Most creams and serums are overly expensive and truly don't do anything. I have spent so much money on luxury facial treatments in the past and now I will not be going back. I love the Renue skin care line.”

– Caitlin H

Acne cleared away

“Renue Transdermal Lotion with Liposomal NAD+ has helped my skin tremendously within the last month that I’ve started using it. I use it at night and my face feels soft and renewed every morning. I’ve struggled with acne and scars and have invested in many products without knowing what the ingredients inside do. I saw potential in Renue’s transdermal lotion because of its ingredients that were scientifically proven to work. Because I believed in the research and science behind the ingredients, I took a dive at this product. I am glad that I found it!”

– Jason H

Improvement in hair quality and growth

"I started using Renue Topical Lotion on my hair as well as my face and neck. I felt I saw some improvement. I see a more pronounced hairline when I look at myself in the mirror. It is my hope that perhaps the hair will darken so it becomes more visible.

Over the month I believe that the scalp condition has improved considerably, the sunspots have disappeared and I believe there has been some improvement in hair quality and growth.”

– William N

This is an amazing product!!!

"Check this out!!!  I've been using the day cream only on my left hand (the hand on the right in this pic) for only one week! 

The day cream has definitely faded some age spots!!!!  It also seems like it's taken some of the wrinkles away.  This is an amazing product!!!”

– Reba W

Every day these lines are less pronounced

“I have been using Renue for about a month now and I am really shocked at the results I am seeing. With the first application I was happy to see a kind of moisturizing effect that I was unfamiliar with. The effect didn’t feel superficial but rather restorative. I’ve tried renue on different parts of my body and it seems to work really well just about anywhere. There are really immediate changes you can see to the surface of your skin after the first few applications, but I’ve found that with a month or so behind me I’m seeing more and more drastic changes. I’m 40 years old and had the fine lines developing under my eyes and on my forehead. Every day these lines are less pronounced. The ones under my eyes have almost vanished. I can’t believe it. It is blowing my mind. Anyway, I wanted to thank the Alive by Science team for making such amazing products all round. I don’t think I’ve ever been more happy with the quality of product and service from a company ever!”

– Terry G

All I can say is WOW!!!

"I recently got this “Renew” skin care product two days ago and this stuff works! I already see a difference, a younger me in the mirror. I gave some to the girls at work as well and they are already seeing results as well. I’ve never had a skin product work immediately as Renue does! I was diagnosed with May Thurner’s syndrome 2 years ago which was found by a blood clot in my left lower leg. The damage from the clot discolored my left lower calve. I’ve been putting Renue on that area every day and have noticed the discolored area looking more normal. I have a couple of Keratosis spots on my face and I’ve been putting Renue on it twice per day. These spots are now almost non-existenet. I’m really amazed by this new skincare product and can’t recommend it enough. The beautiful thing is that I’m only getting started! ABN you guys rock!”

– Dr. Kris F

A massive step forward in the future of skin care

“I have been using it for over a week now on blemishes, scars, under my eyes and just on any marks that generally shouldn’t be on the body.  Again I will personally say… game changing results in the never ending regenerative tissue challenge that we all face as we age.. The first noted benefit was that the dark circles under the eyes virtually disappeared within the first couple of days and the puffiness at this early stage is reduced by at least fifty percent. Kudos to you AliveByNature for introducing the Skin Care Range into your expanding product line. For anyone out there that hasn’t tried Renue. Do yourself a big Favour and give it a go. A massive step forward in the future of skin care.”

– Colby R

The patients are amazed at the results

“Here is an update from the our patients that have been using the skin care line. We have seen fading of age spots, reduced appearance of wrinkles and a new glow to the skin. The patients are amazed at the results they have been getting and we are amazed every day at how well the products work. I have been using the products as well and have seen positive changes.”

Dr. David B

I know it is the best thing I have ever used

“This is an exciting product. I was so excited to try this as I have many solar keratosis on my forearms that never heal and nothing else works. I have noticed a marked difference in some of the stubborn damage that has reduced greatly, some even completely gone. This has never happened with anything else I have tried (I have tried many). I have also been using it on my face and now that I have run out I know it is the best thing I have ever used.I wake up feeling smooth and soft and the skin tone has started to even out in that short time. Keep it up. You guys Rock!

McD NZ

Noticed a tremendous difference

“I have been using this product for six weeks now, and have noticed a tremendous difference in the quality of my skin tone and pore size. I cannot imagine using any other product now.”

– Barcigua

This is truly a breakthrough product!

“Two days is pretty fast for it to start working but I’ve noticed improvements right away. Very noticeable difference in reduction of puffiness of veins on hands from reduced inflammation and improved overall skin texture. Fine lines on face have disappeared and larger wrinkles have diminished. This is truly a breakthrough product!”

– David G

No doubt it visually improves the complexion

“Well this lotion certainly absorbs quickly into the skin and feels great. I was surprised how such a slippery feeling lotion can get absorbed so quickly. I had a bug bite on my face, so it was a little inflamed and it was clearly visible… I must say it was invisible within an hour. It does feel good on the face. I have a couple bumps that look reduced. There is no doubt it visually improves the complexion – the results are noticeable within a few uses. I guess it drives NAD+ up in the dermis dramatically. It does also seem to even out the skin. A nice feeling.”

– Chris B

The fact is the result was smooth, even and not greasy

I received my first shipment of Renue a week ago. I ride my bike most days and sometimes my face gets dry and flakey. I have tried many moisturisers with only one or two showing limited success. On first application, this went on really smooth and did not react with my skin. This sounds like a cosmetic commercial but the fact is the result was smooth, even and not greasy.

– John K

Dramatic improvements to health

Since I’ve moved thru the 60-80 years of my life free of diseases that have killed all my friends and two brothers, I’ve decided to follow Dr. David Sinclair’s research by participating with my body and mind. During the past two years, starting with NMN capsules, then proceeding thru the new products offered, I started correcting body failures. The most dramatic improvements to my health have come from absorbing NAD+ thru my skin with RENUE. This allows complete delivery to my blood stream without ingestive loss though liver filtering.

– Ben Y

Trial

We have had great feedback from customers of our Renue™ Lotion since it was introduced in May 2019, but are even more excited about the potential of our Renue™ Age Defying Serum for restoring and repairing skin ravaged by aging.

Rather than gather feedback haphazardly, we decided to perform our own little trial, and sent an email out to our customer base asking for volunteers that would allow use to use their before and after images in exchange for free product to test.

The first 100 to reply were accepted and were shipped the first bottle of Renue™ Serum just before Thanksgiving 2020. Unfortunately, Covid-19 related shipping delays meant some international shipments took 3 weeks.

We were pleased to find that after 30 days all 100 subjects wanted to continue use, and gave us feedback on what they experienced.   We post their actual responses and summaries below.  You can see the overwhelming majority was extremely positive!

Of course these results are mostly subjective and not proof of anything, but we are very encouraged by them, and believe we will be getting a lot of good before/after images like the one below.

95%  Positive Results after 30 Days

Total- Improvement Noted
54 - firmness
53 - texture & smoothness
49 - skin tone
48 - fine lines or wrinkle
46 - hydration levels
34 - brightening of the skin
27 - under eye area
21 - pigmentation issues
12 - acne issues
12 - hair growth
12 - psoriasis, eczema, rosacea

*Note: 4 of the 5 respondents who had not noticed any change yet had been able to use the product for 1 week or less, due to Covid related shipping delays.

Above are the first few responses.  Click the image to open full results

30 Day Results from Trial Participant

Renue Trial Participant's Results - Before and after Renue Serum
Caitlin's results from using the Renue™ Serum for 30 days

"I've definitely noticed less redness and smoother skin around my eyes and forehead. I LOVE these products. They are the only ones I'd ever use going forward because I see actual results. Most creams and serums are overly expensive and truly don't do anything. I have spent so much money on luxury facial treatments in the past and now I will not be going back. I love the Renue skin care line." - Caitlin H.

Bill's 30 Day Results - Sunspots Gone

Below is an image we received recently from a Renue™ trial participant, Bill, who has been using the Renue™ Age Defying Serum in the morning and evening, 4 pumps each time, massaging it into the scalp.

There is a noticeable diminishment in his sunspots and scalp hyperpigmentation, as well as possible hair growth - and all in a span of one month!

BACKGROUND: I was diagnosed with hypothyroid in 1991. Over the years I have experienced many of the symptoms that hypothyroid brings.  I started using NMN and Resveratrol at or around June 2020. Initially I was taking these products internally only. Upon further investigation my wife discovered Alive by Science products and we ordered the Renue Topical Lotion. Due to my hypothyroid condition, my eyebrows had thinned out to a point where you could barely tell I had any.

I was using Renue Topical Lotion on my face and neck for about 2 months and noticed that my eyebrows had regrown and were actually darker. This discovery encourage me to allow my hair to grow back (until this time I was shaving my head). I started using Renue Topical Lotion on my hair as well as my face and neck. I felt I saw some improvement. I wanted to investigate further for products similar to the lotion so I went on the Alive by Science website and notice they were conducting a trial for the Renue Age Defying Serum. I immediately applied to be a part of the trial. I received the first shipment of product, Renue Age Defying Serum, on November 20, 2020.

PROCEDURE I use the product both morning and evening. I use 4 pumps each time, messaging the serum into the scalp. Photographs for November 20, 2020 Please note the sun damage at the crown of the head

December 10, 2020 Photographs Note: sun damage continues to disappear. Although it is hard to tell I believe that I am seeing new hair growth.

Note: sun damage is gone. The scalp looks refreshed and I believe there was some hair growth although it is hard to tell in these photos. I see a more pronounced hairline when I look at myself in the mirror. It is my hope that perhaps the hair will darken so it becomes more visible.

Over the month I believe that the scalp condition has improved considerably, the sunspots have disappeared and I believe there has been some improvement in hair quality and growth. I received the second shipment of product on December 19, 2020. Along with the Renue Age Defying Serum, I received a canister of Renue Topical Lotion. I will continue the regime of twice a day application with the Renue Age Defying Serum and I will apply the Renue Topical lotion once a day in the mornings. I look forward to the next month with anticipation of more improvement with scalp conditioning and hair growth.

About Renue

RENUE YOUR SKIN

Renue™ delivers the transformative power of NAD+ along with apocynin and resveratrol across the layers of the skin using breakthrough nanoliposome technology. (1)

Restoring NAD+ in the skin has shown to be effective at treating a wide range of skin disorders, returning it to a more youthful state. (2)

NOT A TOPICAL FILLER

Renue™ is a visionary skin care innovation with advanced absorption technology that fortifies the stratum corneum lipids to supercharge skin’s firmness and glow. (1)

PENETRATES TO DEEPEST LAYERS

Renue™ is designed to penetrate through the outermost skin layers to exert lasting effects on deeper layers and other tissues throughout the body. (1)

Advanced bioliposomes power through the harsh layer of the stratum corneum, to renew and repair all seven layers of the skin for maximum anti-aging results.

PROTECTS THE SKIN SURFACE LAYER

Bioidentical liposomes form a shield on the surface layer to defend against daily environmental toxins and maintain lipids in the skin’s moisture barrier. (2)

Dual Action Bioactives

We combined high-performance, science-backed bioactives into a powerhouse nutrient formula that offers dual absorption into the skin cellular matrix.

Renue’s next-generation, youth restoring formula contains skin identical bioliposomes with dual capabilities—protecting the surface layer to the deepest layer.

MAY PROTECT AGAINST INFLAMMATION, DNA DAMAGE

NAD+ can prevent against oxidative stress, DNA damage, senescence and tissue inflammation.7

WORKS AT THE CELLULAR LEVEL

Developed by leading dermatologists, Renue™ is clinically formulated and bioactivated to stimulate healthy cell proliferation and collagen synthesis by renewing the dermal matrix.

NAD+ LEVELS DECLINE WITH AGE

Applying Liposomal NAD+ directly to your skin is the most efficient delivery method. 1

YOUR SKIN IS A RESERVOIR FOR NAD+

Skin is the largest organ in the human body and holds the most NAD+.18

The skin supplies NAD+ to other tissues as needed. 8

 

Renue Your NAD+ Reservoir

INGREDIENTS

Resveratrol

“The Longevity Molecule"

Resveratrol is a stilbenoid polyphenol synthesized by plants in response to stressful stimuli and is protective in aging. 9, 10, 6

Its broad-spectrum properties (antimicrobial, anti-inflammatory, antioxidant and anti-aging) make it a potent bioactive for dermatological application by limiting the effects of cellular aging. 11

Its antioxidant activity (95%) is higher than vitamin E (65%) and C (37%) and has been shown to be active in neutralizing and inhibiting the formation of reactive oxygen species. 6, 12

Apocynin

The Skin Cell Tonic”

Apocynin, a natural vanilloid compound, has emerged as a bioactive phytochemical with potent anti-inflammatory properties for the skin. 13

A new paper published in Nature, found that declining levels of a collagen protein called COL17A1 (Collagen 17), cause our skin to develop wrinkles, sag and lose elasticity. 4

Apocynin was able to restore levels of Collagen 17 and repair damaged skin, leading scientists to believe it’s possible to reverse our skin’s timeline at the cellular level. 14

NAD+

"The Youth Molecule"

May Improve Rosacea

According to research Topical NAD+ has been shown to improve metabolism of skin cells. Its profound antioxidant properties can lessen inflammation that is associated with the damaging effects of free radicals.

May Improve Psoriasis

According to this study, it’s as effective as the leading pharmaceutical at treating psoriasis, and without side effects. NAD+ mitigates cellular damage and lessens inflammation, which leads to a visible improvement in the skin.

More about Resveratrol

More about Apocynin

More about NAD+

Renue™ is concentrated with phytonutrient dense Apocynin, Resveratrol andNAD+, a triple threat against DNA damage and free radicals that lead to skin aging.

These research-backed, anti-aging “powerhouses” work in concert to revitalize the skin’s dynamic nature, prevent transepidermal water loss and replenish the NAD+ reservoir.

RESTORES COLLAGEN, SKIN ELASTICITY

Apocynin is the first substance found to stimulate collagen 17, the deepest layer of collagen. Declining collagen 17 is responsible for wrinkles, sagging skin, and loss of elasticity. (3, 4, 5)

 

  • Dermatologically tested
  • Non-comedogenic
  • Fragrance-free
  • Hypoallergenic
  • Ideal for all skin types
  • Lab tested
  • Paraben and phthalate free

 

 

PROTECTS AGAINST OXIDATIVE STRESS AND UV RADIATION


Resveratrol protects cells against oxidative damage from free radicals and ultraviolet radiation on the skin to slow the process of photoaging.6

LIPOSOMES

Liposomal nanostructures loaded with active compounds drive their precious cargo directly into cells intact. The biomimetic structures are engineered to activate cellular renewal on the skin matrix, stimulate collagen proliferation and improve skin elasticity.

Dual Action Nanoliposomes

Renue is a multifunctional breakthrough in skin science, acting as a double agent to deliver transformative nutrients topically and deep through the harsh layers of strata.

The phytonutrient dense formula forms a breathable, protective shield on the surface layer to defend against daily environmental toxins and maintain lipids in the skin’s moisture barrier.

Liposomal nanostructures loaded with active compounds drive their precious cargo directly into cells intact. The biomimetic structures are engineered to activate cellular renewal on the skin matrix, stimulate collagen proliferation and improve skin elasticity.

Fluidizing Technology

Nanovesicles comprised of natural phosphatidylcholine and oleic acid were chosen to develop liposomes for fluidizing skin without the need of synthetic surfactants or harmful accelerants.

Renue’s fluidizing liposomes have humectant properties that liberate polyphenols previously impossible to isolate into bioavailable form.

This high fluidization temporarily disrupts the hydrolipid film allowing molecules to maintain their pro-oxidant neutralizing efficiency after penetration through the stratum corneum.

The innovative nanosuspension visibly strengthens, regenerates and empowers the skin to renew its life force.

Micro-Stability

Our multifunctional liposomes are enhanced with stabilizing advancements that prevent degradation and maximize therapeutic efficacy.

The multi-dimensional matrix of the cosmetic base provides enhanced stability at room temperature and improves the target specificity of thermosensitive molecules.

The 3D microemulsion is assembled without the use of synthetic surfactants in a heat-free, pressure-free environment with natural co-factors that provide mechanical stability.

Micro-stability helps rebuild the skin matrix and accelerate healthy cell turnover. This improvement of structural stability makes Renue™ more biocompatible over conventional lotions.

Transdermal Delivery

About Liposomes for Transdermal Delivery​

Liposomes have emerged as an important tool for the specific and efficient delivery of various chemical and macromolecular species into the system. Liposomes were discovered in 1965 and designated as swollen phospholipid systems, specifically Banghasomes, by Alec Bangham and his colleagues, and with that paper the liposome “industry” was launched. (https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(10)60950-6.pdf)

They were initially used as models to study biological membranes, and as versatile delivery systems of both hydrophilic and lipophilic molecules (https://www.ncbi.nlm.nih.gov/pubmed/18217339).

What are Liposomes

A Liposome (LY-poh-SOH-m) is a nutrient formulation that contains the active nutrient inside very tiny, fat-like particles. This form is easier for the body to absorb and delivers more nutrients to target areas of the body.

Liposomes are spherical-shaped phospholipid pods filled with aqueous nutrients and indeed represent the most extensively studied and advanced drug and now supplement delivery vehicles.

After extensive research and development efforts, liposome-formulated drugs are now used routinely at clinics to treat  a wide range of illness and disease, mainly because they are biologically inert and biocompatible and do not cause unwanted toxic or immune reactions.

“Since liposomes are made of the same material as most cells, your body recognizes them as a friendly substance”

How are they Absorbed?

Liposomes can be designed to deliver nutrients in multiple ways. Some liposomes work to deliver nutrients by diffusion rather than by ‘direct’ cell fusion.

Other liposomes release nutrient molecules by membrane fusion with the cellular plasma membrane. The nutrient encapsulated in the liposome is protected from metabolism and the molecule becomes active only after release from the liposome sheath, and without degradation. (https://sci-hub.tw/10.1080/01635581.2018.1557212)

They are easily absorbed into the bloodstream through the skin, mucous membranes in your mouth and digestive tract. (https://www.nature.com/articles/s41598-018-31693-y)

Nutraceutical liposomes can act as both curative as well as preventive medicines and so

the nutritional industry’s use of liposomes is expected to grow rapidly in the next 5–10 years. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818067/#b13-33-36)

Transdermal Delivery

The transdermal route is considered a promising path for delivery of molecules into the systemic circulation. Delivery of NAD+ using this route overcomes the limitations of oral therapy and provides a steady state nutrient delivery.

Possible mechanisms of action of liposomes as skin molecule delivery systems.

  1. Free drug mechanism
  2. Penetration enhancing process of liposome components
  3. Vesicle absorption to and/or fusion with the stratum corneum (SC)
  4. Intact vesicle penetration into or into and through the intact skin (not to scale)
  5. Penetration of the vesicles through a hair follicle.

Adapted from EL Maghraby et al., 2008

Topical nutrient delivery across the skin can offer many advantages, such as provide sustained product release, lower oscillations in plasma drug levels, circumvent first-pass metabolism, improve user consistency, and provide local (dermal), or systemic (transdermal) effects (Schäfer-Korting et al., 2007; El Maghraby et al., 2008).

“the transdermal route overcomes the limitations of oral therapy and provides a steady state nutrient delivery”

Dermal and transdermal delivery vehicles in the form of ultra-flexible liposomes, or transferosomes, are increasingly considered the vehicle of choice, mainly because of their high performance as transdermal penetration enhancers and their good stability in suspension. (https://www.nature.com/articles/s41598-018-31693-y#article-info)

Once applied on the skin, liposomes rupture and diffuse as a lipidic mixture that acts as a penetration enhancer. Liposomal topicals and transdermals can optimize cellular uptake and effectiveness and can be easily adjusted to a lower or higher dose to meet each individual’s needs.

“Liposome delivery in lotions overcomes the limitations of oral therapy and provides a steady state nutrient delivery”

The inclusion of lipid vesicles into lotions can enhance their stability, prolong active product release, enhance transdermal permeability, and increase localization of the active within the skin (https://www.intechopen.com/books/liposomes/hydrogels-and-their-combination-with-liposomes-niosomes-or-transfersomes-for-dermal-and-transdermal-).

Absorption and Bioavailability

The advancement of liposomal formulations has led to enhanced transdermal absorption and efficacy, and research has found dermal permeability to be the highest for liposomal formulations. (https://www.sciencedirect.com/science/article/pii/S0753332218352375)

Strong barrier properties of the stratum corneum often limits the efficiency of nutrient delivery through skin. Several approaches have improved permeation of product through the skin for local as well as systemic nutrient delivery.

Incorporation of the drug within flexible liposomal vesicles, or transferosomes, has been one of the popular and well-studied approaches for delivering active product to deeper layers of the skin or even systemic circulation.

(https://www.sciencedirect.com/science/article/abs/pii/S0168365916307015)

“Liposome-formulated compounds are biologically inert and biocompatible and do not cause unwanted toxic or immune reactions”

Recent research has also confirmed that small-sized liposomes greatly increase the kinetics of absorption and lengthen circulation time (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818067/).

These lipid carriers offer the capability of controlling product release, enhancing transdermal absorption and increasing bioavailability of active compounds. Carriers can also target actives to skin appendages and enhance transdermal delivery (https://www.intechopen.com/books/liposomes/hydrogels-and-their-combination-with-liposomes-niosomes-or-transfersomes-for-dermal-and-transdermal-).

Clearance is inversely related to size, with the small unilamellar liposomes and micronized emulsions circulating the blood the longest, leading to longer half-life of the biologically active substance.

“Liposomes seem to be an almost ideal drug-carrier system”

Micro-vesicle technology can act as a platform for the transdermal delivery of various micronutrients such as NAD+ through the skin using fluidizing liposomes incorporated within standard cosmetic bases (https://www.nature.com/articles/s41598-018-34205-0)

Are Transdermal Liposomes Safe

Liposomes seem to be an almost ideal drug-carrier system, since their morphology is similar to that of cellular membranes and because of their ability to incorporate various substances.

They are valued for their biological and technological advantages as optimal delivery systems for biologically active substances, both in vitro and in vivo, and are considered to be the most successful and safe substance-carrier system known to date.

“Nutraceutical liposomes could act as both curative as well as preventive medicines”

Transdermal liposomes are biologically inert and biocompatible and do not cause unwanted toxic or immune reactions (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324542/).

Additional Advantages of Transdermal Delivery of NAD+

Increasing utilization of lotions and hydrogels in transdermal delivery is largely due to their inherent properties, for example - sustained substance release for NAD+ transdermal transport, higher stability, greater percutaneous absorption, desired functionality, and nontoxic nature.

Additional advantages include ease of application, better skin compliance, skin hydration, improved product effectiveness, and convenience.

Liposomes are widely used as carriers due to the small size, both hydrophobic and hydrophilic properties, biodegradability, and high safety.

Several studies, some listed here, have demonstrated the great potential of liposomes as lipid vehicles for NAD+, which are able to enhance drug permeation through he skin and also can act as local depot for the drug to sustain and control its delivery (https://www.intechopen.com/books/liposomes/hydrogels-and-their-combination-with-liposomes-niosomes-or-transfersomes-for-dermal-and-transdermal-).