Renue™ – Topical Lotion with Liposomal NAD+ (150 mL) – ALIVE BY SCIENCE – Bioavailable NAD+ Boosters

Renue™ – Topical Lotion with Liposomal NAD+ (150 mL)

$74.95

Renue™ delivers the transformative power of NAD+ along with Apocynin and Resveratrol across the layers of the skin using breakthrough nanoliposome technology. Renue™ works at the cellular level to deliver time-released actives that restore NAD+ to improve skin’s texture, firmness and dermal matrix.

4 mL (4 pumps) provides 200 mg NAD+ Complex.  Bottle contains 150 mL.

Renue™ is on the optimal 5.5 mark on the pH scale.

In stock

RENUE™ Topical Body Lotion

Renue™ Topical Body Lotion protects and renews cells from within using a proprietary Liposomal NAD+ Complex and science-backed nutrients that provide nourishment on the cellular level.

Expertly formulated with liposomal NAD+ Complex (NAD+, NMN and NR), this potent delivery system offers a deeper penetration of key ingredients into the skin’s surface to combat the most visible signs of aging and promote vibrant, youthful looking skin.

Use day and night with Renue™ Face or Body Serums to restore cellular vitality to all layers of skin. Suitable for all skin types.

 

RENUE™ - 2 Step Skin Rejuvenation Protocol 

 

What's the ideal pH for skin-care products?

You want to look for skin-care products with a pH of 5.5. If anything, they could be as low as 4.5 and as high as 7.  The general rule is slightly acidic is preferred for the best complexion.

What pH are Renue™ Products?

Renue™ NAD+ Skincare products are on the optimal 5.5 mark on the pH scale.

High pH (8 to 14)

Skin-care products with a high pH level (also known as alkaline) pose the biggest threat to your skin's pH and acid mantle. That tight, squeaky-clean feeling you might experience after washing your face is the truest sign of cleansers with a high pH and damaged skin barrier. They, as well as other alkaline skin-care products, tend to strip away sebum and natural oils.

Low pH (1 to 6)

Because products with a low pH are at a level closer to skin's natural pH, they will more effectively work with your skin and help cell turnover gently. They're more likely to keep skin bright and smooth, instead of flaky and angry.

However, certain products can be too low of a pH for skin and irritate it. At-home peels and other acid-spiked products tend to have a lower pH level, making them great exfoliants but just as stripping as products with a high pH.

 

 

 

 

 

Ingredients

Active Ingredients

  • NAD+ Complex: Nicotinamide Adenine Dinucleotide (NAD+) · Nicotinamide Mononucleotide (NMN), Nicotinamide Riboside (NR)
  • Resveratrol
  • Apocynin

Helianthus Annuus (from Sunflower Lecithin) · Aloe Barbadensis (Aloe Vera) · MCT Oil (Coconut Derived) · Shea Butter ·  Tocopherols (Vitamin E) · Rosmarinus officinalis (Rosemary) · Citric acid

Emollients & Stabilizers

Aqua (Water) · Cetearyl Alcohol · Glyceryl Stearate · Phenoxyethanol · Potassium Sorbate · Sodium Benzoate

 

Resveratrol

“The Longevity Molecule"

Resveratrol is a stilbenoid polyphenol synthesized by plants in response to stressful stimuli and is protective in aging. 9, 10, 6

Its broad-spectrum properties (antimicrobial, anti-inflammatory, antioxidant and anti-aging) make it a potent bioactive for dermatological application by limiting the effects of cellular aging. 11

Its antioxidant activity (95%) is higher than vitamin E (65%) and C (37%) and has been shown to be active in neutralizing and inhibiting the formation of reactive oxygen species. 6, 12

Apocynin

The Skin Cell Tonic”

Apocynin, a natural vanilloid compound, has emerged as a bioactive phytochemical with potent anti-inflammatory properties for the skin. 13

A new paper published in Nature, found that declining levels of a collagen protein called COL17A1 (Collagen 17), cause our skin to develop wrinkles, sag and lose elasticity. 4

Apocynin was able to restore levels of Collagen 17 and repair damaged skin, leading scientists to believe it’s possible to reverse our skin’s timeline at the cellular level. 14

NAD+

"The Youth Molecule"

May Improve Rosacea

According to research Topical NAD+ has been shown to improve metabolism of skin cells. Its profound antioxidant properties can lessen inflammation that is associated with the damaging effects of free radicals.

May Improve Psoriasis

According to this study, it’s as effective as the leading pharmaceutical at treating psoriasis, and without side effects. NAD+ mitigates cellular damage and lessens inflammation, which leads to a visible improvement in the skin.

More about Resveratrol

More about Apocynin

More about NAD+

Research

NAD+ Reduces Oxidative Cell Damage

Oxidative stress and chronological aging can cause NAD+ breakdown in the skin. The NAD+ metabolic pathway has been implicated as a therapeutic target to promote cellular health. Recent studies have shown that enhancing NAD+ levels can reduce global oxidative cell damage, replenish total NAD+ stores and restore optimal skin cell function.

Link to research >>

Oleic Acid Enhances Skin Barrier Permeability

Free fatty acids (FFAs), specifically monounsaturated FFAs such as oleic acid, may disrupt skin barrier and act as permeability enhancers for other compounds present in plant oils. Dr. David Sinclair recently stated that he is using Oleic Acid, which stimulates the longevity-linked protein Sirt1 and maintains skin health.

Link to research >>

NAD+ Research for Skin Rejuvenation

Skin aging is driven by both external and internal factors such as sun exposure (UV), stress, environmental toxins and the natural mechanisms of aging occurring in all cells and tissues. Tissues with a high cellular turnover, such as the skin, require higher doses of NAD+ to counteract daily genomic threats, activate sirtuin proteins, and to rejuvenate skin.

Link to research >>

Apocynin Stimulates Growth of Collagen in Deepest Layers of Skin

Apocynin is the only known substance able to stimulate growth of the deepest layers of collagen (COL17A1) and repair damaged skin, leading scientists to say it may be possible to reverse our skin’s timeline at the cellular level. Apocynin is well known as a NADPH oxidase inhibitor and has powerful anti-inflammatory effects on the skin.

Link to research >>

Liposomes an Ideal Carrier system


Liposomes seem to be an almost ideal drug-carrier system. Micro-vesicle technology can act as a platform for the transdermal delivery of various micronutrients such as NAD+ and NMN through the skin using fluidizing liposomes incorporated within standard cosmetic bases. Liposomes circulate the blood the longest, leading to longer half-life of the substance.

Link to research >>

Videos

"I have a skincare product that I am really loving right now & it's a mix between a skincare product & a supplement." - Claudia Glows (Length: 7:37)

"This will really help maintain your levels of collagen." - Madison (Length: 4:38)

"It feels like I'm putting liquid gold on my arm." - Madison (Length: 4:40)

 

"I wish I could take a bath in it." - Claudia Glows (Length: 3:25)

"I'm amazed at the difference I'm seeing." - Claudia Glows (Length: 2:35)

"Overall, this is a powerhouse of ingredients!" - Claudia Glows (Length: 4:13)

 

Testimonials

NAD+ levels in the skin drop as we age. Our Renue skin care products utilize Liposomes to deliver NAD+ to all layers of the skin to help fight the effects of aging on the skin.

Clinical research (in humans) at a top university is ongoing now to verify the beneficial effects of these products.  In the meantime, we have been hearing of a surprisingly wide variety of benefits to the skin, including lessening of wrinkles and age spots, and improvement in appearance in many skin disorders.

The following are uncompensated testimonials from some of our happy customers.

Sun Damage Greatly Diminished

"I applied the serum and day cream to my face after washing it every morning, and before applying my regular SPF moisturizer, and noticed a difference on my skin about 2 months after I started using it. My skin looks brighter, and some sun spots have definitely gotten lighter. I also noticed that the texture of my skin feels like it has more elasticity to it. I love that the products are very light, and absorb quickly. I can't wait to see the results after using it for longer." - Alexia, Age 38.

Renue Skincare Review
Renue Results - Click to View Full Size
Renue Serum Testimonial
Renue Results - Click to View Full Size

Smoother Skin and Less Redness

"I've definitely noticed less redness and smoother skin around my eyes and forehead. I LOVE these products. They are the only ones I'd ever use going forward because I see actual results. Most creams and serums are overly expensive and truly don't do anything. I have spent so much money on luxury facial treatments in the past and now I will not be going back. I love the Renue skin care line." - Caitlin H.

"I have been using Renue for several months on my face, forehead and scalp. Both the serum and the lotion get completely absorbed within minutes. I don't know much about NAD+ but I can tell you it's like pouring the fountain of youth into my tissues. My face is smoother or more even. Skin irritation clears up within minutes.

Renue Hair Growth
Renue Results - Click to View Full Size

Even better, I had skin damage from past sunburns on my forehead. Over 8 weeks using Renue, the rough skin reduced in size and then simply went away! Even better, being 53, I have had a bald spot on my crown for 15 years. Still, I decided to try Renue for that too. I took a before picture about 2.5 months ago. Then I took the same photo just last week. There is no question that the hairs are thicker and that some new hairs have returned. Renue restores youthful skin, repairs damage and seems to literally turn back time. These products are in a league of their own." - Chris B.

NAD+ Skincare
Renue Results - Click to View Full Size

Inflammatory Dermatitis Improved in 2 Weeks

"I see a big improvement on the skin on my forehead. My other dry patches of my inflammatory dermatitis on my cheeks and redness stayed the same where I didn't use Renue. I am hoping for more improvement continuing with this product. I am so happy. I am finally going to start using it on my whole face." - Liz G.

Review Renue Skincare
Click to View Full Size

"Super impressive result. The improvement to my facial skin (& the back of my hands) is absolutely associated with the Renue applications. I had noticed it but when other people started commenting I felt that I had something more concrete to contribute. So in summary this is a remarkable result by any standards. Of course I also take ABS Liposomal NMN & Fisetin amongst a range of other supplements." - Lloyd D.

Renue Skincare Results Vericose Veins
Click to View Full Size

"I have found great results with the Renue Serum! Most specifically and surprisingly in my spider-veins on my left thigh, something I didn’t expect to happen when I decided to try the serum in the first place (wanted to target my fine lines and discoloration in my facial skin - which btw *did* produce results I am happy with) but nothing as much as the clear reduction of my hereditary varicose veins! This first picture was taken Feb 2nd 2021 when I decided to begin applying it there out of simple curiosity, the second image there is a very significant visual reduction in both vein size length and fading pigment back into my skin. " - Michaela B.

Click to View Full Size

“Renue Transdermal Lotion with Liposomal NAD+ has helped my skin tremendously within the last month that I’ve started using it. I use it at night and my face feels soft and renewed every morning. I’ve struggled with acne and scars and have invested in many products without knowing what the ingredients inside do. I saw potential in Renue’s transdermal lotion because of its ingredients that were scientifically proven to work. Because I believed in the research and science behind the ingredients, I took a dive at this product. I am glad that I found it!” - Jason H.

NAD+ Skincare Results
Click to View Full Size

"I am actually astonished looking at these photos.

The creasing under my eyes and the crease of my smile line are significantly reduced as the pigmentation of many of the small “age” spots on my cheek. Pore size has also shrunk." (after 30 days of use) -Anne D.

Renue Skincare Review by Alive By Science
Click to View Full Size

"I was using Renue Topical Lotion on my face and neck for about 2 months and noticed that my eyebrows had regrown and were actually darker. I started using Renue Topical Lotion on my hair as well as my face and neck. Note: sun damage is gone. The scalp looks refreshed and I believe there was some hair growth although it is hard to tell in these photos. I see a more pronounced hairline when I look at myself in the mirror. It is my hope that perhaps the hair will darken so it becomes more visible. Over the month I believe that the scalp condition has improved considerably, the sunspots have disappeared and I believe there has been some improvement in hair quality and growth." - Bill N.

Click to View Full Size

This is an amazing product!!!

"Check this out!!!  I've been using the day cream only on my left hand (the hand on the right in this pic) for only one week! 

The day cream has definitely faded some age spots!!!!  It also seems like it's taken some of the wrinkles away.  This is an amazing product!!!” - Reba W.

 

"I wish I had photographed my hands- the dark spots gone; I alway rubbed remaining serum and cream after applying to face as an "after thought"... Then I realized the dark spots are essentially gone! The face texture is more radiant and skin tone improving - I use religiously morning and nighttime. that plus the NMN powder, AMPK activators and resveratrol. I keep at it. Thanks so much. Photo coming soon. " - Mary R., Age 73

"I LOVE the serum and the lotion! I can’t say enough about this holy grail product! For years I’ve struggled with mild eczema and have tried so many products that promise but fail to deliver. Some products actually irritated my skin further but not Renue skin care. It absorbs quickly and the best thing is that my skin feels the benefits for days after a few times of application! Honestly, it doesn’t even feel like my skin it’s so soft and dry patch free! Also I noticed that several old acne scars are fading within 1 month of trial and no more new dark spots pop out ever after, which is totally amazing!" - Chi Z., Age 30

Recent Renue™ Testimonial - Eczema Improvements

1/25/2021 (before photo)

I have suffered from severe eczema on my hands and feet for over 50 years. For years, my hands would itch so bad from deep under the skin that I would have to run extremely hot water over them to calm the itching. Consequently, afterwards, the cycle would repeat; apply cortisone and wear nitrile gloves to heal the inflamed hands which then led to dryness, cracking and bleeding. I have been using steroids by a Dermatologist to "manage" my eczema in addition to changing diet, etc.

I knew that using high percentage steroids for prolonged periods of time is not healthy which led me to research more natural remedies – some worked briefly – some were a waste of time and money. Eventually, my search let me to NAD+ by Alive by Science and I have to say that I am a very satisfied customer! The picture shows Red, swollen hands with bleeding, dry, cracked fingers and knuckles.

2/9/2021 (2 weeks later, after photo)

After applying NAD+ Renue serum and lotion every day for 2 weeks there was remarkable improvement in the condition of my hands. The pictures really do not tell the actual incredible story. From a comfort perspective, the redness is gone along with the swelling itching, dryness, scaling, cracking and inflammation. Aside from the natural age-related condition, my natural pigment has returned with zero evidence of Eczema – I mean no itching, scaling, bleeding, or dryness! Thank you, NAD+ serum and lotion!

Trial

Our Renue™ Lotion was first introduced in May of 2019 and we've received great feedback on it. Our Renue™ Skincare line has since expanded and we are even more excited about the potential of our Renue™ Age Defying Serum for restoring and repairing skin that is ravaged by aging.

We decided to perform our own little trial, and sent out an email to our customer base asking for volunteers that would allow use to use their before and after images in exchange for free product to test. The first 100 people to reply were accepted and were shipped the first bottle of Renue™ Serum just before Thanksgiving 2020.

Renue Trial
Renue Serum Trial Results

We were pleased to find that after 30 days, all of the 100 subjects wanted to continue use, and gave us feedback on what they experienced. The overwhelming majority was extremely positive!

Of course these results are mostly subjective and not proof of anything, but we are very encouraged by them, and believe we will be getting a lot of good before/after images like the ones below.

Recent Renue™ Testimonial - Eczema Improvements

1/25/2021 (before photo)

I have suffered from severe eczema on my hands and feet for over 50 years. For years, my hands would itch so bad from deep under the skin that I would have to run extremely hot water over them to calm the itching. Consequently, afterwards, the cycle would repeat; apply cortisone and wear nitrile gloves to heal the inflamed hands which then led to dryness, cracking and bleeding. I have been using steroids by a Dermatologist to "manage" my eczema in addition to changing diet, etc.

I knew that using high percentage steroids for prolonged periods of time is not healthy which led me to research more natural remedies – some worked briefly – some were a waste of time and money. Eventually, my search let me to NAD+ by Alive by Science and I have to say that I am a very satisfied customer! The picture shows Red, swollen hands with bleeding, dry, cracked fingers and knuckles.

2/9/2021 (2 weeks later, after photo)

After applying NAD+ Renue serum and lotion every day for 2 weeks there was remarkable improvement in the condition of my hands. The pictures really do not tell the actual incredible story. From a comfort perspective, the redness is gone along with the swelling itching, dryness, scaling, cracking and inflammation. Aside from the natural age-related condition, my natural pigment has returned with zero evidence of Eczema – I mean no itching, scaling, bleeding, or dryness! Thank you, NAD+ serum and lotion!

Bill's 30 Day Results  - Sunspots Diminished

Renue Skincare Review by Alive By Science
Click to View Full Size

Here is an image we received recently from a Renue™ trial participant, Bill, who has been using the Renue™ Age Defying Serum in the morning and evening, 4 pumps each time, massaging it into the scalp.

There is a noticeable diminishment in his sunspots and scalp hyperpigmentation, as well as possible hair growth - and all in a span of one month!
 
Here you can read about Bill's experience, in his own words.

Background

I was using Renue Topical Lotion on my face and neck for about 2 months and noticed that my eyebrows had regrown and were actually darker. Due to my hypothyroid condition, my eyebrows had thinned out to a point where you could barely tell I had any. This discovery encourage me to allow my hair to grow back (until this time I was shaving my head). I started using Renue Topical Lotion on my hair as well as my face and neck. I felt I saw some improvement. I wanted to investigate further for products similar to the lotion so I went on the Alive by Science website and notice they were conducting a trial for the Renue Age Defying Serum. I immediately applied to be a part of the trial. I received the first shipment of product, Renue Age Defying Serum, on November 20, 2020.

Procedure

I use the product both morning and evening. I use 4 pumps each time, messaging the serum into the scalp. Photographs for November 20, 2020 Please note the sun damage at the crown of the head.

December 10, 2020 Photographs - note: sun damage continues to disappear. Although it is hard to tell I believe that I am seeing new hair growth.

Note: sun damage is gone. The scalp looks refreshed and I believe there was some hair growth although it is hard to tell in these photos. I see a more pronounced hairline when I look at myself in the mirror. It is my hope that perhaps the hair will darken so it becomes more visible.

Over the month I believe that the scalp condition has improved considerably, the sunspots have disappeared and I believe there has been some improvement in hair quality and growth. I received the second shipment of product on December 19, 2020. Along with the Renue Age Defying Serum, I received a canister of Renue Topical Lotion. I will continue the regime of twice a day application with the Renue Age Defying Serum and I will apply the Renue Topical lotion once a day in the mornings. I look forward to the next month with anticipation of more improvement with scalp conditioning and hair growth.

About Renue

RENUE YOUR SKIN

Renue™ delivers the transformative power of NAD+ along with apocynin and resveratrol across the layers of the skin using breakthrough nanoliposome technology. (1)

Restoring NAD+ in the skin has shown to be effective at treating a wide range of skin disorders, returning it to a more youthful state. (2)

NOT A TOPICAL FILLER

Renue™ is a visionary skin care innovation with advanced absorption technology that fortifies the stratum corneum lipids to supercharge skin’s firmness and glow. (1)

PENETRATES TO DEEPEST LAYERS

Renue™ is designed to penetrate through the outermost skin layers to exert lasting effects on deeper layers and other tissues throughout the body. (1)

Advanced bioliposomes power through the harsh layer of the stratum corneum, to renew and repair all seven layers of the skin for maximum anti-aging results.

PROTECTS THE SKIN SURFACE LAYER

Bioidentical liposomes form a shield on the surface layer to defend against daily environmental toxins and maintain lipids in the skin’s moisture barrier. (2)

Dual Action Bioactives

We combined high-performance, science-backed bioactives into a powerhouse nutrient formula that offers dual absorption into the skin cellular matrix.

Renue’s next-generation, youth restoring formula contains skin identical bioliposomes with dual capabilities—protecting the surface layer to the deepest layer.

MAY PROTECT AGAINST INFLAMMATION, DNA DAMAGE

NAD+ can prevent against oxidative stress, DNA damage, senescence and tissue inflammation.7

WORKS AT THE CELLULAR LEVEL

Developed by leading dermatologists, Renue™ is clinically formulated and bioactivated to stimulate healthy cell proliferation and collagen synthesis by renewing the dermal matrix.

NAD+ LEVELS DECLINE WITH AGE

Applying Liposomal NAD+ directly to your skin is the most efficient delivery method. 1

YOUR SKIN IS A RESERVOIR FOR NAD+

Skin is the largest organ in the human body and holds the most NAD+.18

The skin supplies NAD+ to other tissues as needed. 8

 

Renue Your NAD+ Reservoir

INGREDIENTS

Resveratrol

“The Longevity Molecule"

Resveratrol is a stilbenoid polyphenol synthesized by plants in response to stressful stimuli and is protective in aging. 9, 10, 6

Its broad-spectrum properties (antimicrobial, anti-inflammatory, antioxidant and anti-aging) make it a potent bioactive for dermatological application by limiting the effects of cellular aging. 11

Its antioxidant activity (95%) is higher than vitamin E (65%) and C (37%) and has been shown to be active in neutralizing and inhibiting the formation of reactive oxygen species. 6, 12

Apocynin

The Skin Cell Tonic”

Apocynin, a natural vanilloid compound, has emerged as a bioactive phytochemical with potent anti-inflammatory properties for the skin. 13

A new paper published in Nature, found that declining levels of a collagen protein called COL17A1 (Collagen 17), cause our skin to develop wrinkles, sag and lose elasticity. 4

Apocynin was able to restore levels of Collagen 17 and repair damaged skin, leading scientists to believe it’s possible to reverse our skin’s timeline at the cellular level. 14

NAD+

"The Youth Molecule"

May Improve Rosacea

According to research Topical NAD+ has been shown to improve metabolism of skin cells. Its profound antioxidant properties can lessen inflammation that is associated with the damaging effects of free radicals.

May Improve Psoriasis

According to this study, it’s as effective as the leading pharmaceutical at treating psoriasis, and without side effects. NAD+ mitigates cellular damage and lessens inflammation, which leads to a visible improvement in the skin.

More about Resveratrol

More about Apocynin

More about NAD+

Renue™ is concentrated with phytonutrient dense Apocynin, Resveratrol andNAD+, a triple threat against DNA damage and free radicals that lead to skin aging.

These research-backed, anti-aging “powerhouses” work in concert to revitalize the skin’s dynamic nature, prevent transepidermal water loss and replenish the NAD+ reservoir.

RESTORES COLLAGEN, SKIN ELASTICITY

Apocynin is the first substance found to stimulate collagen 17, the deepest layer of collagen. Declining collagen 17 is responsible for wrinkles, sagging skin, and loss of elasticity. (3, 4, 5)

 

  • Dermatologically tested
  • Non-comedogenic
  • Fragrance-free
  • Hypoallergenic
  • Ideal for all skin types
  • Lab tested
  • Paraben and phthalate free

 

 

PROTECTS AGAINST OXIDATIVE STRESS AND UV RADIATION


Resveratrol protects cells against oxidative damage from free radicals and ultraviolet radiation on the skin to slow the process of photoaging.6

LIPOSOMES

Liposomal nanostructures loaded with active compounds drive their precious cargo directly into cells intact. The biomimetic structures are engineered to activate cellular renewal on the skin matrix, stimulate collagen proliferation and improve skin elasticity.

Dual Action Nanoliposomes

Renue is a multifunctional breakthrough in skin science, acting as a double agent to deliver transformative nutrients topically and deep through the harsh layers of strata.

The phytonutrient dense formula forms a breathable, protective shield on the surface layer to defend against daily environmental toxins and maintain lipids in the skin’s moisture barrier.

Liposomal nanostructures loaded with active compounds drive their precious cargo directly into cells intact. The biomimetic structures are engineered to activate cellular renewal on the skin matrix, stimulate collagen proliferation and improve skin elasticity.

Fluidizing Technology

Nanovesicles comprised of natural phosphatidylcholine and oleic acid were chosen to develop liposomes for fluidizing skin without the need of synthetic surfactants or harmful accelerants.

Renue’s fluidizing liposomes have humectant properties that liberate polyphenols previously impossible to isolate into bioavailable form.

This high fluidization temporarily disrupts the hydrolipid film allowing molecules to maintain their pro-oxidant neutralizing efficiency after penetration through the stratum corneum.

The innovative nanosuspension visibly strengthens, regenerates and empowers the skin to renew its life force.

Micro-Stability

Our multifunctional liposomes are enhanced with stabilizing advancements that prevent degradation and maximize therapeutic efficacy.

The multi-dimensional matrix of the cosmetic base provides enhanced stability at room temperature and improves the target specificity of thermosensitive molecules.

The 3D microemulsion is assembled without the use of synthetic surfactants in a heat-free, pressure-free environment with natural co-factors that provide mechanical stability.

Micro-stability helps rebuild the skin matrix and accelerate healthy cell turnover. This improvement of structural stability makes Renue™ more biocompatible over conventional lotions.

Transdermal Delivery

Transdermal delivery is a method of applying medications or active ingredients through the skin. It's convenient and can improve product delivery, absorption and effectiveness. The skin's protective barrier creates a challenge for transdermal delivery. As a result, liposomes can be used to carry ingredients past the skin's barrier. (Source)

Liposomes

Liposomes are an advanced delivery vehicle, protecting a much higher percentage of active ingredients from digestion, while slowly releasing the payload into the bloodstream.

  • liposomes improve permeation of products to the site where applied, for localized treatment (in the skin)
  • liposomes also offer systemic nutrient delivery (in the body)
  • liposomal topicals and transdermals can optimize cellular uptake and effectiveness

What Liposomes Are Made Of

A Liposome is made up of a spherical vesicle with the inner contents containing the active ingredients, which are protected by an outer layer comprised of tiny fat-like particles, called the Phospholipid Layer. Liposomes have the ability to carry ingredients that are hydrophobic ("water-fearing") and hydrophilic ("water-loving"). (Source)

Advantages to Transdermal Liposomal Delivery

  • superior stability of active ingredients
  • higher absorption and greater efficacy
  • may circumvent first-pass metabolism - meaning, more of the nutrients will reach your bloodstream
  • enhanced skin permeability, allowing more actives past the outer layer & deeper into the cells
  • the dose is slowly released so the supplement's concentration level can stay fairly constant in the body

Safety of Liposomal Delivery

Liposomes closely resemble the structure of cell membranes, and as a result the body recognizes them as safe and friendly substances (they are biocompatible). Liposome-formulated drugs are used routinely to treat a wide range of illnesses. Nutraceutical or nutritional liposomes can act as both a treatment as well as preventive care. The nutritional industry’s use of liposomes is expected to grow rapidly in the next 5–10 years. (Source, Source)

"Liposomes are valued for their biological and technological advantages, and are considered to be the most successful drug-carrier systems known to date." - International Journal of Nanomedicine, Liposomes As Nanomedical Devices

How Are they Absorbed?

Some liposomes work to deliver nutrients by diffusion, meaning the surface of the skin (stratum corneum) absorbs them, and then transfers the active ingredients directly from the liposomes to the skin.

In addition, lecithin in often used in liposome formulations and it increases the permeability of the skin's surface or barrier, enhancing transdermal delivery. (Source)

The inclusion of lipid vesicles into lotions can enhance their stability, prolong active product release, enhance transdermal permeability, and increase localization of the active within the skin. - Hydrogels and Their Combination with Liposomes, Niosomes, or Transfersomes for Dermal and Transdermal Drug Delivery

Advantages of Transdermal NAD+ on Aging Skin

Accelerated Skin Aging

Accelerated skin aging is common, and it's important to understand some of the causes, in order to address them. Daily exposure to solar radiation contributes to cellular dysfunction within the skin. This results in accelerated skin aging (photoaging), and disturbances to the normal hormeostatic state of the skin. *Homeostasis: This is the condition of optimal functioning within your skin.

Skin's Appearance & Evidence of Damage

Evidence of damage may appear in numerous ways. Chronological aging is characterized by thinning of the skin, which appears as dryness and wrinkles. UV-damaged skin has a thicker, leathery-like appearance with deeper wrinkles and pigmentation issues. (Source)

Cellular NAD+ pools are lower in aged skin. Mitochondria are one of the primary targets of damage from chronological and UV-induced skin aging. (Source, Source)

"Several studies have directly or indirectly linked mitochondrial dysfunction to both chronological and photo-aging of the skin." - Mitochondria in Skin Health, Aging, and Disease, Cell Death & Disease

Mitochondrial Dysfunction & Depletion of NAD+

An increase in oxidative stress contributes to the depletion of NAD+ and ATP (a molecule that carries energy within a cell). The damage contributes to mitochondrial dysfunction in both the short-term & long-term, creating a cumulative impact.

NAD+ Regulates Mitochondrial Maintenance

Mitochondrial maintenance through mitophagy (selectively eliminating the defective mitochondria) and mitochondrial biogenesis (synthesis and production of new mitochondria) is vital to cellular homeostasis and health. (Source)

NAD+ regulates mitochrondrial maintenance. In this study, when levels of NAD+ in old mice were raised, their mitochondrial function was restored to that of young mice. (Source)

"NAD+ and its primary precursor nicotinamide have been known for some time to impact skin homeostasis based on linkages to dietary requirements, treatment of various inflammatory conditions, photoaging..." - The evolving role of the NAD+/nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging

Increasing NAD+ Levels in the Skin

Delivery of NAD+ through transdermal liposomal serums and lotions, is an optimal way to safely raise levels of NAD+ in the skin. In dermal fibroblasts (cells within the dermis), nicotinamide protects against oxidative stress, glycolisis, oxidative phosphorylation and increases mitochondrial efficiency. (Source)

Low NAD+ levels are common in aging skin, and directly contribute to impairement in mitochondrial function and ATP production. Numerous factors contribute to the impaired hormeostatic state of the skin and numerous methods can be used to treat it.

Targeted nutrient therapy with NAD+ and other active ingredients, delivered through transdermal liposomal skincare formulations, is one way to address numerous skin-aging issues. Raising NAD+ levels can create a positive cascading effect on numerous processes.

"Bioactive compounds targeting the mitochondria have proved effective against age-related as well as UV-induced skin damage, in addition to different skin diseases with mitochondrial involvement." - The evolving role of the NAD+/nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging

Renue works at the cellular level

The Renue™ skincare line offers an advanced skin treatment system.

The delivery method is vital when it comes to skincare and supplements. What sets this skincare line apart, in addition to the potent ingredients and scientifically advanced formulation, is its superior mode of delivery.

Liposomes safely carry the active ingredients, which include a NAD+ Complex (NAD+, NMN & NR), Resveratrol and Apocynin, past the outer skin barrier and deep into your cells. The formulation allows for these potent ingredients to reach the target site before releasing them to offer a targeted skin treatment. Learn More.

History of Liposomal Delivery

Liposomes were first discovered in 1965 and soon after were proposed as drug delivery systems. For the last five decades, advancements in this field have led to numerous clinical trials on liposomes for delivery of anti-cancer, anti-fungal, antibiotic drugs, delivery of gene medicines, anesthetics and anti-inflammatory medications. This is an established technology, with a variety of types of liposomes being brought to market. (Source)

Testing