SLC NMN – 60 x 250 mg Capsules

$49.95

For maximum uptake via the SLC12a8 transporter

Impervious to low ph (acidic) environment
Dissolves in high ph of small intestine
Protects NMN from digestion by bacteria in stomach
Sodium Bicarbonate – Maximize absorption
TMG – Methyl Replacement
Zinc – Increased Immunity

In stock

Why SLC NMN – Bioavailability Problem with Standard Capsules

The 2018 Liu/Rabinowitz study found that very little, if any, NMN or NR make it past the liver into the bloodstream.

Even more striking, this 2020 study found most NMN never makes it to the liver, but is almost completely digested by bacteria in the stomach.

The yellow and red bars show NMN and NAD+ in the gastrointestinal tract are many times higher in mice given antibiotics (ABX) or NMN + Antibiotics (NMN + ABX).

This explains why regular NMN capsules perform so poorly compared to sublingual delivery of NMN, that can bypass the stomach and liver to deliver NMN directly to the bloodstream.

The NMN Transporter – SLC12a8

This 2019 study found some NMN (but not NR) can be transported directly through the cell membrane and converted to NAD+ by the newly discovered SLC12a8 enzyme inside the small intestine.

Does the SLC12a8 Transporter mean all NMN capsules are as effective as Sublingual?

No. The quantity that is absorbed utilizing the Slc12a8 enzyme is not thought to be the the majority.

According to the authors:

“It is important to note that the discovery of an NMN transporter by no means diminishes the importance of uptake via dephosphorylation.”

There is hope the Slc12a8 Transporter can be useful.

“Dr. Imai’s lab already has identified small molecules that can stimulate production of the Slc12a8 NMN transporter, applied for patents, and licensed this technology to a company in Japan.”

Doubts about SLC12a8

There are a some die-hard Nicotinamide Riboside (NR) belivers such as Chromadex chief science advisor, Dr. Brenner, who refuse to accept the reseach on Slc12a8 NMN Transporter, but most accept the science.

However, there is huge variation between individuals and testing to quantify how much NMN is actually transported by SLC12a8 has not yet been published. There is much indirect evidence and researchers generally believe it is less than 10% with standard delivery methods.

The Solution – Stop Digestion of NMN by Bacteria in Stomach and Maximize Uptake by SLC12a8 Transporter in Small Intestine

To maximize uptake by the SLC12a8 enzyme, it is necessary to protect NMN from bacteria in the stomach.

Delayed Release™ Capsules

Reaching the small intestines intact is critical to maximize uptake. Our Delayed Release™ capsules have been engineered to make it through the harsh, acidic environment of the stomach without being degraded. They release their payload only when they reach the alkaline environment of the small intestine. This protects NMN from bacteria in the stomach, greatly increasing the quantity that is available for uptake by SLC12a8 enzymes in the small intestine.

Increasing uptake by SLC12a8 NMN transporter

Researchers like Dr. Sinclair are exploring methods to increase uptake by SLC12a8. Sodium is thought to be required, and making it more available may be key.

Sodium for increased uptake

Dr. Huzienga is a very well-known celebrity doctor who has conducted recent trials treating COVID-19 patients with an NMN cocktail—achieving a 100% success rate so far. (See here and here.) On advice from Dr. Sinclair, he uses Sodium Chloride to increase the uptake of NMN by SLC12a8. He also includes TMG to increase methylation and zinc to increase immunity.

Sodium Bicarbonate instead of Sodium Chloride

While Dr. Huzienga has been using Sodium Chloride (table salt) in his NMN cocktail for treating COVID-19, our team has found Sodium Bicarbonate to be a better alternative for long term usage, as many people are trying to limit their salt intake.

SLC Capsules, Sublingual, Liposomal, Intranasal, or Transdermal?

People often ask us what the “best” delivery method is.

If we thought one was capable of restoring NAD+ in all tissues throughout the body, we wouldn’t bother with multiple methods.

Publication of clinical trials at University NSW to measure the NAD+ increase in blood and tissues from several of our products are delayed by COVID-19, but preliminary results are quite positive.

Regardless of how efficient one delivery method is, we do not think it makes sense to try and overload large dosages of NAD+ precursors through a single limited pathway.

It is like trying to fill Lake Tahoe by pouring water down one of the 33 creeks that feed into it. Rainfall over the entire surface and flowing down all the tributaries is a much better solution.

Sublingual is the fastest and most direct to the bloodstream. The majority of users notice increased energy within minutes, but it is filtered out by the liver within 20-30 minutes.

Liposomal delivers some NMN to the bloodstream quickly, with more being protected through the digestive system before reaching the blood. It may take 2-4 hours before liposomes disintegrate and release the NMN, so it is a more “slow release” method, but seems to have the highest overall efficiency.

Transdermal delivery with our Renue™ face and body serums are less efficient at reaching systemic circulation, with much of the NAD+ and precursors being utilized in the skin. However, many users report some difficulty sleeping after applying too much late at night, which seems to be from a significant amount reaching systemic circulation.

Intranasal likely provides the fastest delivery and highest percentage of active ingredients to the brain and bloodstream.

SLC™ Capsules Although SLC12a8 pathway likely does not provide as much active ingredient as other methods, the benefit comes from its ability to utilize a unique pathway, with some NMN being escorted directly into the cell by the Slc12a8 enzyme in the small intestine and the remainder going through the liver

Providing NAD+ and precursors through multiple pathways is best to avoid bottlenecks and feedback loops.

You do not have to take all of them every day.

Alternating several NAD+ precursors is better than pouring money into a single overflowing creek every day.

Testing

testimonials

WHAT OUR CUSTOMERS SAY:

"I take 125 mg before my workouts, 3-5 times a week. During resistance training I see an increased pump. I finish with a rowing machine sprint, and taking NMN gives me a 5-10% increase in distance rowed."

"I have a form of Retinitis Pigmentosa which has been sending me blind for the last 20 years at least.

I have fought it with everything I had but was losing the fight in my late 30s.

It wasn’t until I started the sublingual NMN that I felt definite vision improvements after only one week."

As part of J2Racing he has 3 in-class victories in the Carrera Cup Class of the VLN in recent years.

“I’m a committed bio-hacker with strong goals toward longevity. NAD maintenance is high on my list. I recommend this protocol to people every chance I get.”

"I am the Reigning 65-69 IRONMAN World Champion, a title earned in October 2017 in
Kona, Hawaii. I am able to detect a small “lift” when I take NMN.

I require less sleep and recover faster."

"I was taking the NMN tablets for two years, but find I like the NAD+ tablets and spray better, so have switched to those. At 61, I look at least 15 years younger than others my age. Results from Teloyears were even more encouraging as they showed my telomere length to be that of a 20 year old."

why us

ABOUT ALIVE BY SCIENCE

As the industry leader and largest manufacturer of NAD+ products, we consult with a wide range of research and clinical doctors to understand the latest research and combine that with feedback from tens of thousands of customers on our forum and facebook group. This helps us learn so we can offer the best quality, most effective NAD+ restoration products at the absolute lowest price. Our contributions and constant objectives are:

Moving the science forward
Driving the price down
Setting standards for quality assurance
Customer Service without equal

MOVING THE SCIENCE FORWARD

We constantly strive to improve the effectiveness of our products. So we experiment a lot. We have made great strides improving the bioavailability of NMN and NAD+ products, and enjoy a great reputation among our fast growing customer base as a result.

Sublingual NMN Powder – In 2017 we realized sublingual delivery of NMN is a much more efficient delivery method, so we stopped selling capsules and engineered an NMN powder specifically designed for stability and absorption when taken sublingually. It was an immediate success, as most users can feel a rush of energy, far different than taking a capsule.

Sublingual NMN and NAD+ Tablets – After the success of our NMN Powder, we partnered with the leading pharmaceutical sublingual products formulator to create the first NMN tablets that work similar to the powder in a more convenient form.

NAD+ nasal spray – Delivery to the mucosal membranes to rapidly cross the blood brain barrier for a much different effect than sublingual delivery.

Liposomal NMN, NAD+ and NR - A liposome is a tiny bubble, made out of the same material as a cell membrane, and are used to protect a supplement through the digestive system and deliver intact to the bloodstream. Liposomal Sublingual Gel™ (LSG) is designed for sublingual (under the tongue) use for superior bioavailability. Our proprietary liposomal manufacturing process uses no heat, no pressure and only high-performance, pharmaceutical-grade ingredients.

Renue Skin Care Products with Liposomal NAD+, NMN, and NR - Renue™ delivers the transformative power of NAD+ along with apocynin and resveratrol across the layers of the skin using breakthrough nanoliposome technology. ⁽¹⁾

Restoring NAD+ in the skin has shown to be effective at treating a wide range of skin disorders, returning it to a more youthful state.

We pioneered ALL these advances in NAD+ products in 3 years, with many more coming in 2021, so stay tuned!

DRIVING THE PRICE DOWN

In 2015 when we began producing our own brand of NMN capsules, there were few manufacturers of raw material and the price was exhorbitant.

We believed in the future of NMN, so made the leap and began selling at a break-even prices that were about 1/2 what others were charging, to help spur the markets.

Others were forced to follow our lead and lowered their price almost as low as ours.

We have continued with this model for 5 years now – constantly increasing the size of our orders, and seeing the manufacturing costs drop as more manufacturers see the growing market and learn how to produce the quality product we require.

We’re thrilled to be able to set our retail prices around 1/3 of what they were when we started, and continuously dropping. As always, other companies are forced to lower their prices to match ours, but can’t quite do so as we our the largest buyer and get the best pricing from manufacturers.

SETTING NEW STANDARDS FOR QUALITY

When we started selling NMN on Amazon in 2016, no-one was testing the purity of their product and displaying the proof. Since it is an expensive product and there is no regulatory agency to insure quality, we decided to do so ourselves, and were the first to always post 3rd party test results.

Not only do we test the raw material, but we post test reports for each batch of finished product, as it is simple for a company to just sent a sample off for testing, post that report, but not use any NMN in the bottle

A few have followed our lead now, but many others sell absolute garbage. It is quite easy for a brand new company to pop up and slap a label on some worthless powder, buy some fake reviews on Amazon, and sell bottles to unwitting customers. We had several tested and exposed some of the scammers, but with all the money they can make ripping people off, we couldn't battle all the new brands popping up every week, so left Amazon entirely in 2019.

Dr. Brad Stanfield has taken up the battle a bit and recently tested 21 different brands. Most had less than the advertised quantity of NMN per capsule, with several having NONE. You can see his review here. Unfortunately, that too will have very little effect.

CUSTOMER SERVICE WITHOUT EQUAL

We never adopted the poor customer support standards of other online sellers and don’t outsource phone support to a 3rd party that has no idea what NMN is.

Call us and you will be surprised and the friendly, knowledgeable support.

Our Forum is a great resource for us and our customers to share information and feedback about what works and what doesn't.

We also sponsor trials where we give away free product to hundred of customers and learn more about how they like our products.

We learn from our customers

One big difference between us and other supplement makers is, we actually talk to our customers!

That feedback has proven especially useful in the formulation of NAD+ products, and has helped us determine what works, without waiting years for the clinical research.

WHY ALIVEBYSCIENCE

Whether you want to help support the company driving down prices and moving the science forward with the most effective products, or if you just want the best prices for the best quality NAD+ products, Alive By Science is the place.