ALL ARTICLES AND RESEARCH

Oral Hyaluronic Acid: Advanced Support for Skin, Joint Health and Longevity

  Supplementation with HLA may improve joint function, reduce wrinkles and even extend lifespan. What is Hyaluronic Acid? Hyaluronic acid (a.k.a. hyaluronan, HA, or HLA) is a substance naturally found in many areas of the human body including [...]

David Sinclair’s Supplement Stack and Longevity Strategy

David Sinclair, a professor at Harvard University is perhaps the foremost expert in the growing field of longevity research.  In this video, titled “Dr David Sinclair – Defeating Ageing & Living Longer | Modern Wisdom Podcast 343”, Dr. [...]

NAD+ and the Hallmarks of Aging Series – Part 8: Stem Cell Exaustion

Stem cells – the source of tissue homeostasis In human tissue, there are various highly differentiated cells specialized to perform distinct functions. For example, there are red blood cells for oxygen delivery, muscle cells for movement, neural cells [...]

Does NMN help cancer grow faster?

No. New research shows that it has no impact on tumor growth. People often ask if NMN could promote tumor growth or proliferation of cancer. This study found that NMN supplementation did not have an impact on tumor [...]

Quercetin: A Supercharged Anti-Inflammatory, Anti-viral, Senolytic, and more

  What is Quercetin? The name quercetin comes from the Latin word “Quercetum” which means Oak Forest, belongs to the class called flavonols that cannot be produced in the human body. (Source) Quercetin is said to be one [...]

Glutathione – the mother of all antioxidants

Richard Morgan’s interview with Dr. Alan Green on Modern Healthspan titled “The Importance Of Maintaining Glutathione As We Age | Dr Alan Green Episode 5” Summary of important points: m0:25 – There’s a good research paper out of [...]

Fisetin: The Strongest Known Natural Senolytic

Fisetin Relieves Senescent Cell Burden Fisetin, a naturally occurring plant flavonoid protects the body from accumulating harmful waste and activates Sirtuins, proteins responsible for regulating cellular health and aging.  (Source) Functioning as a “senolytic,” clearing away dysfunctional senescent [...]

Longevity Key—Calcium Alpha-Ketoglutarate

  CaAKG Extends Healthspan in Mice by 10-16% A multi-year, controlled study, conducted by the Buck Institute for Research on Aging in aged mice, found that calcium alpha-ketoglutarate (Ca-AKG), a stable form of alpha-ketoglutarate (AKG), promotes a longer, [...]

Trimethylglycine (TMG) for restoring methylation, homocysteine levels, heart health, and liver function

TMG – the insurance policy against loss of methyl groups TMG is one of the most important ways to restore methyl groups because as the name implies, it has three methyl groups to donate. “The reason I take [...]

New research finds NR may be harmful for heart function in mice

Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication This study examined  the effect on NAD+ levels from DNA damage leading to heart failure in mice, and the efficacy of Nicotinamide Riboside (NR) supplementation to [...]

Small Dose of NMN Restores Fertility in Old Mice, Large Dose Does Not – Implications for Dosage Suggestions

Recently published research shows that a small dose of NMN in the drinking water was able to improve the quality of eggs in older mice and reverse infertility. Researchers at the Universities of Queensland and New South Wales  [...]

New Research Shows NMN May Enhance Aerobic Capacity

Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study In this six-week human study published July 8, 2021, researchers conclude that supplementation of Nicotinamide Mononucleotide (NMN) remarkably lifted ventilatory threshold (VT) in amateur runners. [...]

New research shows NMN may protect and restore skin from UV damage

In two new studies, NMN was shown to play a vital role in protecting and reducing damage to skin from the harmful effects of UV radiation. Repeated exposure to UV radiation has been shown to prematurely age the [...]

Multiple pathways for NAD+ uptake by cells – regulated by SIRT1

SIRT1-dependent restoration of NAD+ homeostasis after increased extracellular NAD+ exposure In this study, researchers investigated how intracellular NAD+ (iNAD) levels are regulated in several different types of healthy cells exposed to extracellular NAD+ (eNAD). They found that iNAD+ [...]

NMN is most effective at restoring intracellular NAD+

This new research examines what happens to NR, NMN and other metabolites of NAD+ in the bloodstream and how they effect intracellular NAD+ levels in peripheral tissues. Degradation of Extracellular NAD+ Intermediates in Cultures of Human HEK293 Cells(Nikiforov, [...]

Recent change in formula for Sublingual NMN tablets

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Study Shows NMN Supplementation or CD38 Inhibition Restores Cardiovascular Function in Mice

CD38 Deficiency Alleviates Ang II-Induced Vascular Remodeling By Inhibiting Small Extracellular Vesicle-Mediated Vascular Smooth Muscle Cell Senescence In Mice (Lu Gan, June 2021) In this study, researchers investigated the impact of NMN supplementation and CD38 inhibition on the [...]

FIND OUT IF YOUR ANTI-AGING PROTOCOL IS WORKING

NEAR TERM – INTRACELLULAR NAD+ TEST Maintaining high NAD+ levels provides the fuel your cells need to repair damage and fight the aging process. Besides aging, many factors can effect your NAD+ levels in the near term, such [...]

Bacteria in Gastrointestional Tract Metabolize NMN and Impact NAD+ Metabolome

This recently published research by Drs. Lindsay Wu, David Sinclair and others examined the pathways that oral NMN takes to becoming NAD+ in mice. It confirmed some aspects of earlier research, and also made some surprising new findings. [...]

Reduced Nicotinamide Mononucleotide – A Tale of Four NAD+ Precursors

NAD+ precursors and healthy aging Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells. It is a critical coenzyme for energy metabolism and also serves as the substrate for enzymes such as the sirtuins. One [...]

NMN IS BIOAVAILABLE AND STABLE IN BLOOD – NR IS NOT

NMN IS STABLE IN THE BLOODSTREAM, NR IS NOT Bioavailability is the fraction of an administered dose of unchanged drug that reaches the systemic circulation Since the Rabinowitz study in 2018, we have known that both Nicotinamide Riboside [...]

NAD+ and the Hallmarks of Aging Series – Part 7: Cellular senescence

Cellular senescence – Aging at the cellular level Cellular senescence is generally defined as a loss of the ability to divide followed by some secretive phenotypes. This phenomenon is first described by Hayflick in 1961, which is primarily [...]

NAD+ and the Hallmarks of Aging Series – Part 6: Mitochondrial Dysfunction

Mitochondria – more than power plants in cells Mitochondria are the large organelles that exist in most human cells. They are the critical organelles that generate ATP through the respiratory chain and produce the intermediate metabolites that are [...]

NAD+ and the Hallmarks of Aging Series – Part 5: Deregulated Nutrient Sensing

Overview Currently, available evidence strongly supports the idea that anabolic signaling (the signal that promotes growth and proliferation) accelerates aging, and decreased nutrient signaling extends longevity (Fontana et al., 2010). Further, a pharmacological manipulation that mimics a state [...]

NAD+ and the Hallmarks of Aging Series – Part 4: Loss of Proteostasis

Cells are “factories” and proteins are “machines” In previous parts, we mainly discussed the mishaps that accumulate on the genome that cause aging. In this article, we will move our focus to protein. When talking about proteins, the [...]

NAD+ and the Hallmarks of Aging Series – Part 3: Epigenetic Alteration

What is epigenetics? It is well-known that the DNA sequence inside of the nucleus encodes all the information required for life. However, why do different cells/tissues work very differently even though they share the same genome? The answer [...]

NAD+ and the Hallmarks of Aging Series – Part 2: Telomere attrition

Telomere shortening is probably the most famous hallmark of aging, but what is the telomere’€s original function?   Telomeres protect the ends of chromosomes Every complex organism is based on the proliferation of the cells. The cells must [...]

NAD+ and the Hallmarks of Aging Series – Part 1: Genomic instability

Aging characterized by gradual loss of physiological integrity Aging is characterized by a gradual loss of physiological integrity, resulting in impaired biological function and increased vulnerability to diseases and death. In 2013, Lopez-otin et al first summarized the [...]

Bioavailability Issues

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Sublingual Delivery

SUBLINGUAL PRODUCTS   [...]

Renue Age Defying Serum Trial

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NAD+ for Metabolism and Brain, NMN for the body?

Do NMN and NAD⁺ have different effects on the body? Researchers use supplementation with NMN, NR and NAD⁺ to restore levels of NAD⁺ in mice, making them look and behave like they did when young and extending their [...]

Is SLC12A8 a dedicated NMN transporter – Dr Stanfield questions Dr Brenner

Above is a response by Dr. Bradley Stanfield to some lingering questions that resulted from an interview he had of Dr. Charles Brenner on Dec. 6th, 2020. The original interview by Dr. Stanfield can be seen in it’s [...]

First Randomized Clinical Trial: NMN increases muscle insulin sensitivity in prediabetic women

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women, Science, April 22, 2021 NAD+ is the critical cellular component for cellular homeostasis, which declines during the aging process. Various studies have shown that decreased NAD+ levels are associated [...]

Why TOO MUCH NMN or NR is bad, and what you can do about it

If not protected, NMN and NR supplements are almost entirely degraded to NAM (Nicotinamide) before reaching tissues beyond the liver. While NAM is beneficial for many health conditions, excessive NAM levels can be detrimental to your health. “high [...]

RESVERATROL FOR SKIN

BROAD SPECTRUM SKIN PROTECTION Resveratrol exhibits a remarkable range of biological activities, including anti-inflammatory, anti-oxidant, anti-viral, cardioprotective, neuroprotective and anti-aging properties. According to a recent study found that found Resveratrol effective at treating moderately photo-damaged skin: “Resveratrol is [...]

NAD⁺ Injection Restores NAD⁺ Levels in Brain and Cognition in Mice

In a recent study, 18 male APP/PS1 mice were intraperitoneally injected with 30 mg/kg NAD⁺ at 20 weeks of age and once every other day for 4 weeks. These transgenic mice were used as they develop the behavioral [...]

Renue Videos

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Justin Bieber gets weekly IV drips of NAD+

  Justin Bieber gets weekly IV drips of NAD+ to help with the effects of his years of substance abuse   Justin Bieber opened up about his substance abuse, mental health, and recovery process on his new YouTube [...]

NMN product shows increased endurance and new blood vessel growth in mice

This new research, published March 22 in Cell, identifies the key cellular mechanisms behind vascular aging and the key role it plays on muscle health. Scientists at Harvard Medical School, Massachusetts Institute of Technology (MIT) and the University of [...]

NAD+ For Skin Care

An essential compound—known as NAD+—has found its way into skincare and is being hailed as a “true cosmeceutical.” [...]

Which NAD+ Booster is right for me?

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CD73 utilization shows importance of NMN to restore NAD+

This recent study found that in endothelial cells, the extracellular conversion of NMN to NR by CD73 enzyme in the cell membrane is a key mechanism to maintain intracellular NAD+ Reversal of endothelial dysfunction by nicotinamide mononucleotide via [...]

NAD+ is the Transport Molecule Used by the Body, Not Nicotinamide Riboside

Restoring NAD+ levels in older animals and humans is at the center of efforts to slow or even stop the effects of aging. One method being researched is providing supplements  such as Nicotinamide Riboside (NR) that the body [...]

Sublingual delivery of NAD+ boosters

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What is NAD+?

Poor Bioavailability from Capsules NAD+ not effective in drinking water or in capsule form The NAD+ molecule is twice as large as NR or NMN, and is totally degraded in the gastrointestinal tract, so researchers do not use [...]

How NAD+ Boosts ATP and What it Means for Health and Aging

Much of the attention on the benefits of restoring NAD+ levels focus on its role in activating sirtuins. However, scientific research shows that NAD supplementation has a clear beneficial effect not only on ageing itself but also on [...]

1st NMN Human Study Demonstrates Safety and Faster Utilization than NR

The first study of NMN in humans was just published. https://www.jstage.jst.go.jp/…/advpub_EJ19-03…/_pdf/-char/en This japanese study looked at a single dose of 100, 250, or 500 mg NMN capsules to 10 men 40-60 years old. No adverse effects were noted. [...]

NAD+ IV increases NAD+ levels in blood plasma 400% in humans

This study was just published that documented changes in plasma and urine levels of NAD+ and its metabolites during and after 750 mg NAD+ intravenous (IV) infusion. A Pilot Study Investigating Changes in the Human Plasma and Urine [...]

NMN Improves Cerebrovascular Function and Cognition in Mice

Decreased NAD+ levels are implicated in a wide range of age related impairments. There is  evidence that restoring NAD+ by treatment with nicotinamide mononucleotide (NMN) may reverse age-related dysfunction in multiple organs. For instance, prior research showed supplementation [...]

Slc12a8 does not solve the bioavailability problem for NMN Capsules

This research was published in January 2019 that found an enzyme named Slc12a8 that can transport a small quantity of Nicotinamide Mononucleotide (NMN) directly into some cells. However, this enzyme is only prevalent in the small intestine of [...]

Increased NAD+ in Bloodstream of Nursing Mice Results in Healthier, Stronger, Smarter Offspring

This study fed lactating mice Nicotinamide Riboside (NR) in chow for 21 days after birth of offspring to measure the effect on the health of their pups who did not receive any NR. After 21 days, the pups [...]

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Scientists discover SLC12a8 pathway used by NMN to restore NAD+ levels

Yes, NMN can cross the cell membrane intact This research was just published that found an enzyme named Slc12a8 that can transport a small quantity of Nicotinamide Mononucleotide (NMN) directly into some cells However, this enzyme is only [...]

Tru Niagen vs Basis

As you’re reading this, there are mind-boggling advances being made in longevity and anti-aging. In fact, just a couple of years ago, scientists were able to reverse the age of mice by up to 40 years simply by [...]

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Is Basis by Elysium Health a Hoax?

The main ingredient in Elysium Health’s Basis is Nicotinamide Riboside (NR). Elysium Health is only one of several companies selling Nicotinamide Riboside (NR). Their main selling point is the 6 Nobel Prize winning scientists they have signed up [...]

Exogenous NAD+ Increases Metabolism

Effects of Chronic NAD Supplementation on Energy Metabolism and Diurnal Rhythm in Obese Mice In a study published in 2018, scientists gave obese mice 1 mg/kg of NAD+ by inter peritoneal injection for 4 weeks, which  restored NAD+ levels [...]

Rick Simpson, 67 – Reigning Ironman Age Group Champion

I am the Reigning 65-69 IRONMAN World Champion, a title earned in October 2017 in Kona, Hawaii UPDATES FROM RICK Received and am using NMN you sent, 5xscoops per day at with scoops at intervals greater than 1 [...]

David Giacometti, 60 – Cyclist

I’m interested in signing up for the contest for older athletes. I’m a 60 year old male who competes in cycling. The biggest event I’ve raced in is the Tulsa Tough competition held in June each year, although [...]

Success Spotlight – Real People Real Results

COMPETITIVE SPORTS We feel that improvements in this category are the strongest proof possible, outside of long term clinical trials. These are older athletes who have a long history of competition. Sudden, dramatic improvement in their performance after [...]