Research with NAD+

NMN is most effective at restoring intracellular NAD+

This new research examines what happens to NR, NMN and other metabolites of NAD+ in the bloodstream and how they effect intracellular NAD+ levels in peripheral tissues. Degradation of Extracellular NAD+ Intermediates in Cultures of Human HEK293 Cells(Nikiforov, [...]

14
Dec

NAD+ is the Transport Molecule Used by the Body, Not Nicotinamide Riboside

Restoring NAD+ levels in older animals and humans is at the center of efforts to slow or even stop the effects of aging. One method being researched is providing supplements  such as Nicotinamide Riboside (NR) that the body [...]

16
Aug

Sublingual delivery of NAD+ boosters

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10
Apr

NAD+ for Metabolism and Brain, NMN for the body?

Do NMN and NAD⁺ have different effects on the body? Researchers use supplementation with NMN, NR and NAD⁺ to restore levels of NAD⁺ in mice, making them look and behave like they did when young and extending their [...]

10
Apr

What is NAD+?

Poor Bioavailability from Capsules NAD+ not effective in drinking water or in capsule form The NAD+ molecule is twice as large as NR or NMN, and is totally degraded in the gastrointestinal tract, so researchers do not use [...]

10
Apr

How NAD+ Boosts ATP and What it Means for Health and Aging

Much of the attention on the benefits of restoring NAD+ levels focus on its role in activating sirtuins. However, scientific research shows that NAD supplementation has a clear beneficial effect not only on ageing itself but also on [...]

08
Dec

NAD⁺ Injection Restores NAD⁺ Levels in Brain and Cognition in Mice

In a recent study, 18 male APP/PS1 mice were intraperitoneally injected with 30 mg/kg NAD⁺ at 20 weeks of age and once every other day for 4 weeks. These transgenic mice were used as they develop the behavioral [...]

18
Nov

NAD+ IV increases NAD+ levels in blood plasma 400% in humans

This study was just published that documented changes in plasma and urine levels of NAD+ and its metabolites during and after 750 mg NAD+ intravenous (IV) infusion. A Pilot Study Investigating Changes in the Human Plasma and Urine [...]

22
Sep

Exogenous NAD+ Increases Metabolism

Effects of Chronic NAD Supplementation on Energy Metabolism and Diurnal Rhythm in Obese Mice In a study published in 2018, scientists gave obese mice 1 mg/kg of NAD+ by inter peritoneal injection for 4 weeks, which  restored NAD+ levels [...]

25
Sep

NAD+ Supplements Regulate Energy Metabolism via the Hypothalamus

Exogenous nicotinamide adenine dinucleotide regulates energy metabolism via hypothalamic Connexin 43. There are some very important findings coming out of this research: Exogenous NAD+ definitely does cross the blood brain barrier through the Connexin 43 gap junction Exogenous [...]

06
Dec

NAD+ Supplements – Research and Benefits

Nicotinamide Adenide Dinucleotide (NAD+) and its immediate precursor Nicotinamide Mononucleotide (NMN) have both been shown to quickly elevate levels of NAD+ in various tissues and organs throughout the body. [...]

11
Aug