HOW MUCH SHOULD I TAKE?
250 to 2,000 mg a day, depending on your age, health, and the delivery method.
But, don’t waste your money taking HUGE doses of inefficient NAD+ Boosters.
For example, when taken as capsules, NR is mostly degraded to NAM as noted by the authors of this study
Oral NR dosing increased circulating NAM 40-fold while NMN remained unchanged and NR was detected only at trace levels in the blood.
Research has not found a benefit from taking 1,000 mg of NR capsules per day vs 300-500 mg per day. Large dosages result in massive increases of NAM which must be methylated so it can be excreted, which may lead to problems from shortage of methyl donors.
With sublingual delivery, you can take somewhat larger dosages before you max out, so we recommend up to 1,000 mg a day.
Liposomal delivery is best as it provides a sustained release of payload in the bloodstream which is far more efficient at lower dosages, without the problem of excessive NAM production at higher dosages.
Regardless of how efficient the delivery method is, we believe providing NAD+ and precursors through multiple pathways is best to avoid bottlenecks and feedback loops.
We recommend 2,000 mg per day only if you use multiple delivery methods, or liposomal delivery spread out over multiple dosages during the day.
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